Seroatlas · Human Serome Atlas

KCNH3

Voltage-gated inwardly rectifying potassium channel KCNH3

Also known as: BEC1, elk2, KCNH3_HUMAN, Kv12.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULD8
Gene: KCNH3
Ensembl: ENSG00000135519
Chromosome: 12
Canonical length: 1083 aa
Protein class: Predicted membrane proteins, Transporters, Voltage-gated ion channels

OverviewNCBI Gene

The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

1083 residues, UniProt reviewed canonical sequence.

>Q9ULD8|KCNH3
     1  MPAMRGLLAP QNTFLDTIAT RFDGTHSNFV LGNAQVAGLF PVVYCSDGFC DLTGFSRAEV
    61  MQRGCACSFL YGPDTSELVR QQIRKALDEH KEFKAELILY RKSGLPFWCL LDVIPIKNEK
   121  GEVALFLVSH KDISETKNRG GPDRWKETGG GRRRYGRARS KGFNANRRRS RAVLYHLSGH
   181  LQKQPKGKHK LNKGVFGEKP NLPEYKVAAI RKSPFILLHC GALRATWDGF ILLATLYVAV
   241  TVPYSVCVST AREPSAARGP PSVCDLAVEV LFILDIVLNF RTTFVSKSGQ VVFAPKSICL
   301  HYVTTWFLLD VIAALPFDLL HAFKVNVYFG AHLLKTVRLL RLLRLLPRLD RYSQYSAVVL
   361  TLLMAVFALL AHWVACVWFY IGQREIESSE SELPEIGWLQ ELARRLETPY YLVGRRPAGG
   421  NSSGQSDNCS SSSEANGTGL ELLGGPSLRS AYITSLYFAL SSLTSVGFGN VSANTDTEKI
   481  FSICTMLIGA LMHAVVFGNV TAIIQRMYAR RFLYHSRTRD LRDYIRIHRI PKPLKQRMLE
   541  YFQATWAVNN GIDTTELLQS LPDELRADIA MHLHKEVLQL PLFEAASRGC LRALSLALRP
   601  AFCTPGEYLI HQGDALQALY FVCSGSMEVL KGGTVLAILG KGDLIGCELP RREQVVKANA
   661  DVKGLTYCVL QCLQLAGLHD SLALYPEFAP RFSRGLRGEL SYNLGAGGGS AEVDTSSLSG
   721  DNTLMSTLEE KETDGEQGPT VSPAPADEPS SPLLSPGCTS SSSAAKLLSP RRTAPRPRLG
   781  GRGRPGRAGA LKAEAGPSAP PRALEGLRLP PMPWNVPPDL SPRVVDGIED GCGSDQPKFS
   841  FRVGQSGPEC SSSPSPGPES GLLTVPHGPS EARNTDTLDK LRQAVTELSE QVLQMREGLQ
   901  SLRQAVQLVL APHREGPCPR ASGEGPCPAS TSGLLQPLCV DTGASSYCLQ PPAGSVLSGT
   961  WPHPRPGPPP LMAPWPWGPP ASQSSPWPRA TAFWTSTSDS EPPASGDLCS EPSTPASPPP
  1021  SEEGARTGPA EPVSQAEATS TGEPPPGSGG LALPWDPHSL EMVLIGCHGS GTVQWTQEEG
  1081  TGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 72 nTPM
amygdala: 57 nTPM
hippocampal formation: 56 nTPM
basal ganglia: 33 nTPM
pituitary gland: 20 nTPM
cerebellum: 13 nTPM

Single-cell type

epididymal clear cells: 51 nCPM
brain excitatory neurons: 50 nCPM
gonadotrophs: 38 nCPM
respiratory ciliated cells: 36 nCPM
brain inhibitory neurons: 33 nCPM
epididymal efferent duct ciliated cells: 29 nCPM

Immune cell

naive CD8 T-cell: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 83 nTPM
hippocampal formation: 76 nTPM
amygdala: 75 nTPM
white matter: 63 nTPM
basal ganglia: 56 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 3.85
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNH3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNH3 as an antibody target. Whether an autoantibody or antibody against KCNH3 could matter depends on whether native KCNH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNH3 is annotated at the cell surface, where native KCNH3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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