KCNE3
Potassium voltage-gated channel subfamily E member 3
Also known as: HOKPP, KCNE3_HUMAN, MiRP2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y6H6
- Gene
- KCNE3
- Ensembl
- ENSG00000175538
- Chromosome
- 11
- Canonical length
- 103 aa
- Protein class
- Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
- Subcellular location
- Plasma membrane
OverviewNCBI Gene
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
103 residues, UniProt reviewed canonical sequence.
>Q9Y6H6|KCNE3
1 METTNGTETW YESLHAVLKA LNATLHSNLL CRPGPGLGPD NQTEERRASL PGRDDNSYMY
61 ILFVMFLFAV TVGSLILGYT RSRKVDKRSD PYHVYIKNRV SMILocalizationUniProt · AlphaFold · HPA
Whether an antibody against KCNE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 66 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 66 nTPM
- stomach: 53 nTPM
- rectum: 44 nTPM
- small intestine: 38 nTPM
- colon: 33 nTPM
- thyroid gland: 31 nTPM
Single-cell type
- kupffer cells: 133 nCPM
- neutrophils: 130 nCPM
- megakaryocytes: 99 nCPM
- gastric progenitor cells: 87 nCPM
- mucous neck cells: 86 nCPM
- neutrophil progenitors: 74 nCPM
Immune cell
- neutrophil: 53 nTPM
- basophil: 52 nTPM
- intermediate monocyte: 42 nTPM
- classical monocyte: 39 nTPM
- non-classical monocyte: 37 nTPM
- eosinophil: 24 nTPM
Brain region
- choroid plexus: 14 nTPM
- white matter: 9.3 nTPM
- thalamus: 8.1 nTPM
- medulla oblongata: 7.2 nTPM
- pons: 6.9 nTPM
- midbrain: 6.4 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about KCNE3.
Disease | AllUniProt
Conditions KCNE3 is implicated in, by any mechanism.
- Brugada syndrome 6 (BRGDA6) MIM:613119
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.49
- gnomAD pLI
- 0.47
- gnomAD missense Z
- 0.24
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- intracellular chloride ion homeostasis
- membrane repolarization during action potential
- membrane repolarization during ventricular cardiac muscle cell action potential
- negative regulation of delayed rectifier potassium channel activity
- negative regulation of potassium ion export across plasma membrane
- potassium ion export across plasma membrane
- regulation of heart rate by cardiac conduction
- regulation of ventricular cardiac muscle cell membrane repolarization
- sodium ion transport
- ventricular cardiac muscle cell action potential
- negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential
Molecular functions
- potassium channel regulator activity
- transmembrane transporter binding
- voltage-gated potassium channel activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Potassium channel, voltage-dependent, beta subunit, KCNE
- Slow voltage-gated potassium channel
- Potassium channel, voltage-dependent, beta subunit, KCNE3
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of KCNE3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KCNE3 as an antibody target. Whether an autoantibody or antibody against KCNE3 could matter depends on whether native KCNE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KCNE3 is annotated at the cell surface, where native KCNE3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label KCNE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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