Seroatlas · Human Serome Atlas

KANSL3

KAT8 regulatory NSL complex subunit 3

Also known as: FLJ10081, KANL3_HUMAN, KIAA1310, NSL3, Rcd1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2N6
Gene
KANSL3
Ensembl
ENSG00000114982
Chromosome
2
Canonical length
904 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Involved in regulation of mitochondrial transcription. Located in mitochondrion and nucleoplasm. Part of NSL complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q9P2N6|KANSL3
     1  MAHRGGERDF QTSARRMGTS LLFQLSVHER ELDLVFLDHS YAKPWSAHPD ASSARPTRML
    61  FVTPRRQHES TIESDVPIDV ETVTSTPMPL YDNQKARSVM NECERHVIFA RTDADAPPPP
   121  EDWEEHVNRT GWTMAQNKLF NKILKALQSD RLARLANEGA CNEPVLRRVA VDKCARRVRQ
   181  ALASVSWDTK LIQWLHTTLV ETLSLPMLAA YLDALQTLKG KIPTLIDRML VSSNTKTGAA
   241  GAEALSLLLK RPWDPAVGVL SHNKPSKLPG SPLILIASSG PSSSVFPTSR RHRFWQSQLS
   301  CLGKVIPVAT HLLNNGSGVG VLQCLEHMIG AVRSKVLEIH SHFPHKPIIL IGWNTGALVA
   361  CHVSVMEYVT AVVCLGFPLL TVDGPRGDVD DPLLDMKTPV LFVIGQNSLQ CHPEAMEDFR
   421  EKIRAENSLV VVGGADDNLR ISKAKKKSEG LTQSMVDRCI QDEIVDFLTG VLTRAEGHMG
   481  SEPRDQDAEK KKKPRDVARR DLAFEVPERG SRPASPAAKL PASPSGSEDL SSVSSSPTSS
   541  PKTKVTTVTS AQKSSQIGSS QLLKRHVQRT EAVLTHKQAQ AQFAAFLKQN MLVRKALPPG
   601  TSSCLFVPIS SEPPEEGEKE DLRVQLKRHH PSSPLPGSKT SKRPKIKVSL ISQGDTAGGP
   661  CAPSQGSAPE AAGGKPITMT LGQASAGAKE LTGLLTTAKS SSSEGGVSAS PVPSVVSSST
   721  APSALHTLQS RLVATSPGSS LPGATSASSL LQGLSFSLQD ISSKTSGLPA NPSPGPAPQA
   781  TSVKLPTPMQ SLGAITTGTS TIVRTIPVAT TLSSLGATPG GKPTAIHQLL TNGGLAKLAS
   841  SLPGLAQISN QASGLKVPTT ITLTLRGQPS RITTLSPMGS GAAPSEESSS QVLPSSSQRL
   901  PPAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KANSL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 32 nTPM
  • tongue: 20 nTPM
  • parathyroid gland: 14 nTPM
  • bone marrow: 14 nTPM
  • seminal vesicle: 14 nTPM
  • endometrium: 13 nTPM

Single-cell type

  • myonuclei: 182 nCPM
  • distal convoluted tubule cells: 108 nCPM
  • renal collecting duct intercalated cells: 95 nCPM
  • renal connecting tubule cells: 95 nCPM
  • rod photoreceptor cells: 80 nCPM
  • cardiomyocytes: 79 nCPM

Immune cell

  • NK-cell: 3.1 nTPM
  • gdT-cell: 2.8 nTPM
  • memory CD8 T-cell: 2.8 nTPM
  • basophil: 2.4 nTPM
  • naive CD8 T-cell: 2.3 nTPM
  • MAIT T-cell: 2.1 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • thalamus: 8.8 nTPM
  • spinal cord: 8.1 nTPM
  • cerebral cortex: 6.8 nTPM
  • midbrain: 6.8 nTPM
  • hypothalamus: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
2.47
DepMap mean gene effect
-1
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KANSL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KANSL3 as an antibody target. Whether an autoantibody or antibody against KANSL3 could matter depends on whether native KANSL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KANSL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KANSL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KANSL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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