Seroatlas · Human Serome Atlas

JRKL

Jerky protein homolog-like

Also known as: HHMJG, JERKL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4A0
Gene: JRKL
Ensembl: ENSG00000183340
Chromosome: 11
Canonical length: 524 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytokinetic bridge

OverviewNCBI Gene

The function of this gene has not yet been defined, however, the encoded protein shares similarity with the human (41% identical) and mouse (34% identical) jerky gene products. This protein may act as a nuclear regulatory protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

524 residues, UniProt reviewed canonical sequence.

>Q9Y4A0|JRKL
     1  MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE KIITYASSSD
    61  STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP ICAKRAEFFF YALGMDGDFN
   121  PSAGWLTRFK QRHSIREINI RNERLNGDET AVEDFCNNFR DFIERENLQP EQIYNADETG
   181  LFWKCLPSRI SVIKGKCTVP GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST
   241  DTLNLPVSYF SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE
   301  NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG NDLKSFWKKL
   361  TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF DVEDISVATV AAILQHTKGL
   421  ENVTTENLEK WLEVDSTEPG YEVLTDSEII RRAQGQADES SENEEEEIEL IPEKHINHAA
   481  ALQWTENLLD YLEQQGDMIL PDRLVIRKLR ATIRNKQKMT KSSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JRKL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

ovary: 11 nTPM
retina: 10 nTPM
testis: 10 nTPM
fallopian tube: 9.5 nTPM
cervix: 9.2 nTPM
thyroid gland: 9 nTPM

Single-cell type

early spermatids: 327 nCPM
late spermatids: 128 nCPM
late primary spermatocytes: 71 nCPM
sertoli cells: 47 nCPM
respiratory ciliated cells: 25 nCPM
tuft cells: 23 nCPM

Immune cell

plasmacytoid DC: 4.1 nTPM
basophil: 3.3 nTPM
naive CD4 T-cell: 3.2 nTPM
naive CD8 T-cell: 3 nTPM
classical monocyte: 2.6 nTPM
eosinophil: 2.6 nTPM

Brain region

hypothalamus: 8.3 nTPM
white matter: 8 nTPM
thalamus: 7.3 nTPM
medulla oblongata: 7.1 nTPM
midbrain: 7.1 nTPM
pons: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 1.74
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JRKL as an antibody target. Whether an autoantibody or antibody against JRKL could matter depends on whether native JRKL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JRKL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JRKL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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