Seroatlas · Human Serome Atlas

JRK

Jerky protein homolog

Also known as: jerky, JERKY_HUMAN, JH8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75564
Gene: JRK
Ensembl: ENSG00000234616
Chromosome: 8
Canonical length: 556 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nuclear bodies

OverviewNCBI Gene

This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

556 residues, UniProt reviewed canonical sequence.

>O75564|JRK
     1  MASKPAAGKS RGEKRKRVVL TLKEKIDICT RLEKGESRKA LMQEYNVGMS TLYDIRAHKA
    61  QLLRFFASSD SNKALEQRRT LHTPKLEHLD RVLYEWFLGK RSEGVPVSGP MLIEKAKDFY
   121  EQMQLTEPCV FSGGWLWRFK ARHGIKKLDA SSEKQSADHQ AAEQFCAFFR SLAAEHGLSA
   181  EQVYNADETG LFWRCLPNPT PEGGAVPGPK QGKDRLTVLM CANATGSHRL KPLAIGKCSG
   241  PRAFKGIQHL PVAYKAQGNA WVDKEIFSDW FHHIFVPSVR EHFRTIGLPE DSKAVLLLDS
   301  SRAHPQEAEL VSSNVFTIFL PASVASLVQP MEQGIRRDFM RNFINPPVPL QGPHARYNMN
   361  DAIFSVACAW NAVPSHVFRR AWRKLWPSVA FAEGSSSEEE LEAECFPVKP HNKSFAHILE
   421  LVKEGSSCPG QLRQRQAASW GVAGREAEGG RPPAATSPAE VVWSSEKTPK ADQDGRGDPG
   481  EGEEVAWEQA AVAFDAVLRF AERQPCFSAQ EVGQLRALRA VFRSQQQETV GLEDVVVTSP
   541  EELAIPKCCL EASTET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JRK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 11 nTPM
ovary: 8.2 nTPM
kidney: 7.7 nTPM
cervix: 7.1 nTPM
skeletal muscle: 6.9 nTPM
spleen: 6.9 nTPM

Single-cell type

foveolar cells: 29 nCPM
salivary duct cells: 25 nCPM
esophageal apical cells: 24 nCPM
undifferentiated spermatogonia: 23 nCPM
differentiating spermatogonia: 22 nCPM
podocytes: 20 nCPM

Immune cell

naive CD4 T-cell: 1.3 nTPM
naive B-cell: 1.2 nTPM
basophil: 1 nTPM
memory CD4 T-cell: 1 nTPM
naive CD8 T-cell: 1 nTPM
eosinophil: 0.9 nTPM

Brain region

cerebellum: 20 nTPM
cerebral cortex: 19 nTPM
white matter: 17 nTPM
medulla oblongata: 17 nTPM
thalamus: 17 nTPM
amygdala: 16 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of canonical Wnt signaling pathway

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JRK as an antibody target. Whether an autoantibody or antibody against JRK could matter depends on whether native JRK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JRK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB).

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