Seroatlas · Human Serome Atlas

JKAMP

JNK1/MAPK8-associated membrane protein

Also known as: C14orf100, CDA06, HSPC213, HSPC327, JAMP, JKAMP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P055
Gene: JKAMP
Ensembl: ENSG00000050130
Chromosome: 14
Canonical length: 311 aa
Protein class: Cancer-related genes, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables ubiquitin protein ligase binding activity. Involved in ERAD pathway. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q9P055|JKAMP
     1  MAVDIQPACL GLYCGKTLLF KNGSTEIYGE CGVCPRGQRT NAQKYCQPCT ESPELYDWLY
    61  LGFMAMLPLV LHWFFIEWYS GKKSSSALFQ HITALFECSM AAIITLLVSD PVGVLYIRSC
   121  RVLMLSDWYT MLYNPSPDYV TTVHCTHEAV YPLYTIVFIY YAFCLVLMML LRPLLVKKIA
   181  CGLGKSDRFK SIYAALYFFP ILTVLQAVGG GLLYYAFPYI ILVLSLVTLA VYMSASEIEN
   241  CYDLLVRKKR LIVLFSHWLL HAYGIISISR VDKLEQDLPL LALVPTPALF YLFTAKFTEP
   301  SRILSEGANG H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JKAMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 53 nTPM
kidney: 41 nTPM
choroid plexus: 39 nTPM
spinal cord: 35 nTPM
adrenal gland: 33 nTPM
thyroid gland: 32 nTPM

Single-cell type

late primary spermatocytes: 206 nCPM
early spermatids: 170 nCPM
kupffer cells: 96 nCPM
extravillous trophoblasts: 88 nCPM
fallopian tube ciliated cells: 87 nCPM
late spermatids: 83 nCPM

Immune cell

neutrophil: 90 nTPM
basophil: 87 nTPM
non-classical monocyte: 83 nTPM
eosinophil: 82 nTPM
intermediate monocyte: 75 nTPM
plasmacytoid DC: 71 nTPM

Brain region

choroid plexus: 47 nTPM
pons: 41 nTPM
white matter: 41 nTPM
hypothalamus: 38 nTPM
medulla oblongata: 38 nTPM
midbrain: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about JKAMP.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 46 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with seizures and impaired intellectual and language development
JKAMP-associated neurodevelopmental disease
JKAMP neurodevelopmental disorder
JKAMP-related neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.08
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase binding

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

JNK1/MAPK8-associated membrane protein
JNK1/MAPK8-associated membrane protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JKAMP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JKAMP as an antibody target. Whether an autoantibody or antibody against JKAMP could matter depends on whether native JKAMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JKAMP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JKAMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...