Seroatlas · Human Serome Atlas

IRX3

Iroquois-class homeodomain protein IRX-3

Also known as: IRX-1, IRX3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78415
Gene: IRX3
Ensembl: ENSG00000177508
Chromosome: 16
Canonical length: 501 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>P78415|IRX3
     1  MSFPQLGYQY IRPLYPSERP GAAGGSGGSA GARGGLGAGA SELNASGSLS NVLSSVYGAP
    61  YAAAAAAAAA QGYGAFLPYA AELPIFPQLG AQYELKDSPG VQHPAAAAAF PHPHPAFYPY
   121  GQYQFGDPSR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN
   181  ARRRLKKENK MTWAPRSRTD EEGNAYGSER EEEDEEEDEE DGKRELELEE EELGGEEEDT
   241  GGEGLADDDE DEEIDLENLD GAATEPELSL AGAARRDGDL GLGPISDSKN SDSEDSSEGL
   301  EDRPLPVLSL APAPPPVAVA SPSLPSPPVS LDPCAPAPAP ASALQKPKIW SLAETATSPD
   361  NPRRSPPGAG GSPPGAAVAP SALQLSPAAA AAAAHRLVSA PLGKFPAWTN RPFPGPPPGP
   421  RLHPLSLLGS APPHLLGLPG AAGHPAAAAA FARPAEPEGG TDRCSALEVE KKLLKTAFQP
   481  VPRRPQNHLD AALVLSALSS S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 83 nTPM

Expression across tissuesHPA

Tissue

skin: 83 nTPM
breast: 71 nTPM
heart muscle: 59 nTPM
salivary gland: 41 nTPM
kidney: 38 nTPM
epididymis: 34 nTPM

Single-cell type

breast lactating cells: 280 nCPM
platelets: 234 nCPM
epididymal principal cells: 210 nCPM
breast hormone-responsive cells: 181 nCPM
alveolar cells type 2: 166 nCPM
respiratory ciliated cells: 163 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 17 nTPM
medulla oblongata: 16 nTPM
thalamus: 16 nTPM
pons: 13 nTPM
spinal cord: 13 nTPM
cerebellum: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.89
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRX3 as an antibody target. Whether an autoantibody or antibody against IRX3 could matter depends on whether native IRX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRX3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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