Seroatlas · Human Serome Atlas

IRX2

Iroquois-class homeodomain protein IRX-2

Also known as: IRX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZI1
Gene: IRX2
Ensembl: ENSG00000170561
Chromosome: 5
Canonical length: 471 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>Q9BZI1|IRX2
     1  MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG SAAFTAQAAT
    61  GFGSPLQYSA DAAAAAAGFP SYMGAPYDAH TTGMTGAISY HPYGSAAYPY QLNDPAYRKN
   121  ATRDATATLK AWLNEHRKNP YPTKGEKIML AIITKMTLTQ VSTWFANARR RLKKENKMTW
   181  APRNKSEDED EDEGDATRSK DESPDKAQEG TETSAEDEGI SLHVDSLTDH SCSAESDGEK
   241  LPCRAGDPLC ESGSECKDKY DDLEDDEDDD EEGERGLAPP KPVTSSPLTG LEAPLLSPPP
   301  EAAPRGGRKT PQGSRTSPGA PPPASKPKLW SLAEIATSDL KQPSLGPGCG PPGLPAAAAP
   361  ASTGAPPGGS PYPASPLLGR PLYYTSPFYG NYTNYGNLNA ALQGQGLLRY NSAAAAPGEA
   421  LHTAPKAASD AGKAGAHPLE SHYRSPGGGY EPKKDASEGC TVVGGGVQPY L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 27 nTPM
skin: 25 nTPM
breast: 23 nTPM
lung: 17 nTPM
kidney: 15 nTPM
stomach: 14 nTPM

Single-cell type

breast lactating cells: 798 nCPM
alveolar cells type 1: 253 nCPM
breast myoepithelial cells: 216 nCPM
pancreatic islet cells: 194 nCPM
gastric chief cells: 174 nCPM
basal keratinocytes: 155 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 47 nTPM
medulla oblongata: 29 nTPM
midbrain: 17 nTPM
cerebellum: 10 nTPM
thalamus: 10 nTPM
spinal cord: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.02
gnomAD missense Z: 0.56
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRX2 as an antibody target. Whether an autoantibody or antibody against IRX2 could matter depends on whether native IRX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...