Seroatlas · Human Serome Atlas

IRX1

Iroquois-class homeodomain protein IRX-1

Also known as: IRX-5, IRX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78414
Gene: IRX1
Ensembl: ENSG00000170549
Chromosome: 5
Canonical length: 480 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

480 residues, UniProt reviewed canonical sequence.

>P78414|IRX1
     1  MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG GAGAAAVTSV
    61  LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD NPGVHPATFA AHTAPAYYPY
   121  GQFQYGDPGR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN
   181  ARRRLKKENK VTWGARSKDQ EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ
   241  SNEDDEDKAE APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG
   301  AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA PLQHPAFLPS
   361  HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA PHGPHLPAPP PPQPPVAIAP
   421  GALNGDKASV RSSPTLPERD LVPRPDSPAQ QLKSPFQPVR DNSLAPQEGT PRILAALPSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

kidney: 23 nTPM
salivary gland: 15 nTPM
breast: 14 nTPM
skin: 7.6 nTPM
adipose tissue: 6.1 nTPM
midbrain: 4.3 nTPM

Single-cell type

breast lactating cells: 231 nCPM
breast myoepithelial cells: 111 nCPM
breast secretory cells: 64 nCPM
bergmann glia: 38 nCPM
salivary myoepithelial cells: 38 nCPM
loop of henle epithelial cells: 28 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 37 nTPM
medulla oblongata: 28 nTPM
midbrain: 22 nTPM
spinal cord: 16 nTPM
thalamus: 14 nTPM
cerebellum: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRX1 as an antibody target. Whether an autoantibody or antibody against IRX1 could matter depends on whether native IRX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...