INTS7

Protein identityUniProt · HPA

UniProt accession

Q9NVH2

Gene

INTS7

Ensembl

ENSG00000143493

Chromosome

1

Canonical length

962 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nuclear bodies

OverviewNCBI Gene

This gene encodes a subunit of the integrator complex. The integrator complex associates with the C-terminal domain of RNA polymerase II and mediates 3'-end processing of the small nuclear RNAs U1 and U2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

962 residues, UniProt reviewed canonical sequence.

>Q9NVH2|INTS7
     1  MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR LFQKYPFPIL
    61  INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV DEFVKRIFSV IHSNDPVARA
   121  ITLRMLGSLA SIIPERKNAH HSIRQSLDSH DNVEVEAAVF AAANFSAQSK DFAVGICNKI
   181  SEMIQGLATP VDLKLKLIPI LQHMHHDAIL ASSARQLLQQ LVTSYPSTKM VIVSLHTFTL
   241  LAASSLVDTP KQIQLLLQYL KNDPRKAVKR LAIQDLKLLA NKTPHTWSRE NIQALCECAL
   301  QTPYDSLKLG MLSVLSTLSG TIAIKHYFSI VPGNVSSSPR SSDLVKLAQE CCYHNNRGIA
   361  AHGVRVLTNI TVSCQEKDLL ALEQDAVFGL ESLLVLCSQD DSPGAQATLK IALNCMVKLA
   421  KGRPHLSQSV VETLLTQLHS AQDAARILMC HCLAAIAMQL PVLGDGMLGD LMELYKVIGR
   481  SATDKQQELL VSLATVIFVA SQKALSVESK AVIKQQLESV SNGWTVYRIA RQASRMGNHD
   541  MAKELYQSLL TQVASEHFYF WLNSLKEFSH AEQCLTGLQE ENYSSALSCI AESLKFYHKG
   601  IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA TTIAMTLGND
   661  LQRCGRISNQ MKQSMEEFRS LASRYGDLYQ ASFDADSATL RNVELQQQSC LLISHAIEAL
   721  ILDPESASFQ EYGSTGTAHA DSEYERRMMS VYNHVLEEVE SLNRKYTPVS YMHTACLCNA
   781  IIALLKVPLS FQRYFFQKLQ STSIKLALSP SPRNPAEPIA VQNNQQLALK VEGVVQHGSK
   841  PGLFRKIQSV CLNVSSTLQS KSGQDYKIPI DNMTNEMEQR VEPHNDYFST QFLLNFAILG
   901  THNITVESSV KDANGIVWKT GPRTTIFVKS LEDPYSQQIR LQQQQAQQPL QQQQQRNAYT
   961  RF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

20 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.55

gnomAD pLI

0

gnomAD missense Z

2.13

DepMap mean gene effect

-1.15

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to ionizing radiation
• DNA damage checkpoint signaling
• regulation of transcription elongation by RNA polymerase II
• RNA polymerase II transcription initiation surveillance
• snRNA 3'-end processing
• snRNA processing

Cellular components

• chromosome
• cytoplasm
• INTAC complex
• integrator complex
• nuclear body
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Armadillo-type fold
• Integrator complex subunit 7
• Integrator complex subunit 7, C-terminal domain
• Integrator complex subunit 7, N-terminal
• Integrator complex subunit 7, helical bundle
• Integrator complex subunit 7, C-terminal domain
• Integrator complex subunit 7, N-terminal
• Integrator complex subunit 7 helical bundle

KeywordsUniProt

• Chromosome
• Cytoplasm
• DNA damage
• Nucleus
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of INTS7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NABP2
• PPP2CA