Seroatlas · Human Serome Atlas

ILRUN

Protein ILRUN

Also known as: C6orf106, dJ391O22.4, FLJ22195, ILRUN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6K1
Gene: ILRUN
Ensembl: ENSG00000196821
Chromosome: 6
Canonical length: 298 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes a protein with N-terminal ubiquitin-associated (UBA)-like and central neighbor of BRCA1 gene 1 (NBR1)-like domains. The protein acts an inhibitor of antiviral and proinflammatory cytokine transcription and as a regulator of the renin-angiotensin-aldosterone system (RAAS). [provided by RefSeq, Jul 2021]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>Q9H6K1|ILRUN
     1  MEGMDVDLDP ELMQKFSCLG TTDKDVLISE FQRLLGFQLN PAGCAFFLDM TNWNLQAAIG
    61  AYYDFESPNI SVPSMSFVED VTIGEGESIP PDTQFVKTWR IQNSGAEAWP PGVCLKYVGG
   121  DQFGHVNMVM VRSLEPQEIA DVSVQMCSPS RAGMYQGQWR MCTATGLYYG DVIWVILSVE
   181  VGGLLGVTQQ LSSFETEFNT QPHRKVEGNF NPFASPQKNR QSDENNLKDP GGSEFDSISK
   241  NTWAPAPDTW APAPDQTEQD QNRLSQNSVN LSPSSHANNL SVVTYSKGLH GPYPFGQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ILRUN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 202 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 202 nTPM
tongue: 175 nTPM
liver: 75 nTPM
heart muscle: 72 nTPM
cerebellum: 66 nTPM
testis: 63 nTPM

Single-cell type

late spermatids: 596 nCPM
neutrophils: 263 nCPM
early spermatids: 233 nCPM
retinal ganglion cells: 189 nCPM
adipocytes: 185 nCPM
myonuclei: 176 nCPM

Immune cell

basophil: 24 nTPM
T-reg: 10 nTPM
gdT-cell: 8.9 nTPM
non-classical monocyte: 8.3 nTPM
naive B-cell: 8.2 nTPM
eosinophil: 8.1 nTPM

Brain region

midbrain: 96 nTPM
cerebral cortex: 95 nTPM
cerebellum: 90 nTPM
thalamus: 83 nTPM
pons: 78 nTPM
medulla oblongata: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.85
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ILRUN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IRF3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ILRUN as an antibody target. Whether an autoantibody or antibody against ILRUN could matter depends on whether native ILRUN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ILRUN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ILRUN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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