Seroatlas · Human Serome Atlas

IL2RB

Interleukin-2 receptor subunit beta

Also known as: CD122, IL15RB, IL2RB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14784
Gene
IL2RB
Ensembl
ENSG00000100385
Chromosome
22
Canonical length
551 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. The use of alternative promoters results in multiple transcript variants encoding the same protein. The protein is primarily expressed in the hematopoietic system. The use by some variants of an alternate promoter in an upstream long terminal repeat (LTR) results in placenta-specific expression. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>P14784|IL2RB
     1  MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ DGALQDTSCQ
    61  VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT VDIVTLRVLC REGVRWRVMA
   121  IQDFKPFENL RLMAPISLQV VHVETHRCNI SWEISQASHY FERHLEFEAR TLSPGHTWEE
   181  APLLTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT
   241  IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV
   301  QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS SNHSLTSCFT
   361  NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP TGSSPQPLQP LSGEDDAYCT
   421  FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP
   481  DLVDFQPPPE LVLREAGEEV PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ
   541  ELQGQDPTHL V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL2RB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
46 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 46 nTPM
  • bone marrow: 33 nTPM
  • lymph node: 33 nTPM
  • tonsil: 22 nTPM
  • placenta: 21 nTPM
  • appendix: 20 nTPM

Single-cell type

  • nk-cells: 288 nCPM
  • extravillous trophoblasts: 203 nCPM
  • t-cells: 81 nCPM
  • innate lymphoid cells: 50 nCPM
  • epididymal basal cells: 16 nCPM
  • respiratory basal cells: 6.8 nCPM

Immune cell

  • NK-cell: 184 nTPM
  • gdT-cell: 50 nTPM
  • total PBMC: 34 nTPM
  • memory CD8 T-cell: 28 nTPM
  • MAIT T-cell: 27 nTPM
  • T-reg: 25 nTPM

Brain region

  • medulla oblongata: 1.3 nTPM
  • thalamus: 1.2 nTPM
  • amygdala: 0.6 nTPM
  • pons: 0.6 nTPM
  • spinal cord: 0.6 nTPM
  • white matter: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL2RB.

Disease | AllUniProt

Conditions IL2RB is implicated in, by any mechanism.

  • Immunodeficiency 63 with lymphoproliferation and autoimmunity (IMD63) MIM:618495

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 495 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 63 with lymphoproliferation and autoimmunity
  • Ichthyosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.29
gnomAD missense Z
0.44
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL2RB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL2RB as an antibody target. Whether an autoantibody or antibody against IL2RB could matter depends on whether native IL2RB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL2RB is annotated at the cell surface, where native IL2RB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL2RB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL2RB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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