Seroatlas · Human Serome Atlas

IKBIP

Inhibitor of nuclear factor kappa-B kinase-interacting protein

Also known as: FLJ31051, IKIP, IKIP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q70UQ0
Gene
IKBIP
Ensembl
ENSG00000166130
Chromosome
12
Canonical length
350 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli rim,Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be involved in response to X-ray. Predicted to act upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; response to interleukin-1; and response to tumor necrosis factor. Located in endoplasmic reticulum and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q70UQ0|IKBIP
     1  MSEVKSRKKS GPKGAPAAEP GKRSEGGKTP VARSSGGGGW ADPRTCLSLL SLGTCLGLAW
    61  FVFQQSEKFA KVENQYQLLK LETNEFQQLQ SKISLISEKW QKSEAIMEQL KSFQIIAHLK
   121  RLQEEINEVK TWSNRITEKQ DILNNSLTTL SQDITKVDQS TTSMAKDVGL KITSVKTDIR
   181  RISGLVTDVI SLTDSVQELE NKIEKVEKNT VKNIGDLLSS SIDRTATLRK TASENSQRIN
   241  SVKKTLTELK SDFDKHTDRF LSLEGDRAKV LKTVTFANDL KPKVYNLKKD FSRLEPLVND
   301  LTLRIGRLVT DLLQREKEIA FLSEKISNLT IVQAEIKDIK DEIAHISDMN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IKBIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 25 nTPM
  • urinary bladder: 16 nTPM
  • smooth muscle: 15 nTPM
  • appendix: 15 nTPM
  • adipose tissue: 14 nTPM
  • blood vessel: 12 nTPM

Single-cell type

  • neutrophils: 166 nCPM
  • plasma cells: 108 nCPM
  • extravillous trophoblasts: 98 nCPM
  • hepatic stellate cells: 78 nCPM
  • monocyte progenitors: 77 nCPM
  • decidual stromal cells: 76 nCPM

Immune cell

  • neutrophil: 28 nTPM
  • eosinophil: 19 nTPM
  • basophil: 11 nTPM
  • classical monocyte: 6.4 nTPM
  • memory B-cell: 6 nTPM
  • non-classical monocyte: 5.7 nTPM

Brain region

  • choroid plexus: 8.3 nTPM
  • white matter: 5.7 nTPM
  • medulla oblongata: 4.8 nTPM
  • thalamus: 4.6 nTPM
  • hypothalamus: 4.2 nTPM
  • spinal cord: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.39
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Inhibitor of nuclear factor kappa-B kinase-interacting protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IKBIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IKBIP as an antibody target. Whether an autoantibody or antibody against IKBIP could matter depends on whether native IKBIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IKBIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IKBIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IKBIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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