IGSF22

Protein identityUniProt · HPA

UniProt accession

Q8N9C0

Gene

IGSF22

Ensembl

ENSG00000179057

Chromosome

11

Canonical length

903 aa

Protein class

Predicted intracellular proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

No narrative summary is available for IGSF22 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

903 residues, UniProt reviewed canonical sequence.

>Q8N9C0|IGSF22
     1  MTTIHSRQML QEHVSMEFSS STTHVQTFSQ TTKIVGEEVV RRKSSSIVEF FSLVTRSSNI
    61  PAGDSVPEFV EKPQPVTAPE GDKAVFRARV QGNAKPHISW KRESGIPIKE SAKIFYDSIN
   121  KEHVLKLEPL TSDDSDNYKC IASNDHADAI YTVSLLVTEG QEKMDFKKML KKRAPPAPKK
   181  KQKKVANEKE MLEILSKVPK KDFEKVCMEY GFTDFRGLLR KLKEMKKKVE VEAIRILKPL
   241  EDKETKVDTT VVFDCIMELK DPNVKMIWIK GTEPLRIQYS LGKYDVKQMG TKYMLVISNV
   301  NMNDAGIYSL SVGDKRMSAE LTVLDEPLKF LGEMKPVKVT ERQTAVFEIR LSKKEPNFVW
   361  KFNGKELKRD DKYEITVSED GLTHTLKIKD ARLSDSGEFS AEAGNLVQKA QLTVDRIPIK
   421  FVSNLKNVRV KERSRACLEC ELTSKDVTLR WKKDGQLLMH GTKYSMNHEG KRAELIIEDA
   481  QLSDGGEYTV VAMQDGDPTE YYSTAIVTVE ERLATVKSGM SDVHAATGSP AELCVVLNDE
   541  KVEGVWLKDG KEITDLPGMQ IVKQGAVHKL IFPSMGPEHE GKYTFRAKGT ESEASVFIAD
   601  PPTIDPSVLE ALAAHAITVK VGHTAHIKVP FRGKPLPKVT WYKDGMEVTE EERVSMERGE
   661  DQALLTISNC VREDSGLILL KLKNDHGSAT ATLHLSVLEP PGFASQPQVT DVTKEAVTIT
   721  WNAPTQDGGA PVLGYIVERR KKGSNLWVPV NKDPIQGTKC TVDGLLEDTE YEFRVIAVNK
   781  AGPGQPSVPS SSVVAKDPVK PPGLVQDLHV SDSSNSSISL AWREPAEGDP PSGYILEMRA
   841  EDTKEWSKCT KIPISGTCYT VGGLIERQKY FFRIRAVNEA GVGEPVELDK GVRAMPPPGL
   901  TTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGSF22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

1.2

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Fibronectin type III
• Immunoglobulin-like domain
• Immunoglobulin I-set
• Immunoglobulin-like fold
• Fibronectin type III superfamily
• Immunoglobulin-like domain superfamily
• MyBP-C, tri-helix bundle domain
• Striated Muscle Structural and Regulatory Protein
• Fibronectin type III domain
• Immunoglobulin I-set domain
• Tri-helix bundle domain

KeywordsUniProt

• Immunoglobulin domain
• Repeat