Seroatlas · Human Serome Atlas

IFITM2

Interferon-induced transmembrane protein 2

Also known as: 1-8D, DSPA2c, IFM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q01629
Gene: IFITM2
Ensembl: ENSG00000185201
Chromosome: 11
Canonical length: 132 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

Canonical amino-acid sequenceUniProt

132 residues, UniProt reviewed canonical sequence.

>Q01629|IFITM2
     1  MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE TSVPDHVVWS
    61  LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGIFMTILL
   121  IIIPVLVVQA QR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFITM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 1,506 nTPM

Expression across tissuesHPA

Tissue

spleen: 1,506 nTPM
liver: 1,338 nTPM
lung: 1,149 nTPM
adipose tissue: 1,130 nTPM
blood vessel: 933 nTPM
fallopian tube: 814 nTPM

Single-cell type

neutrophils: 3,451 nCPM
decidual stromal cells: 339 nCPM
platelets: 253 nCPM
neutrophil progenitors: 208 nCPM
nk-cells: 173 nCPM
vascular endothelial cells: 158 nCPM

Immune cell

neutrophil: 23,258 nTPM
eosinophil: 3,762 nTPM
basophil: 2,685 nTPM
non-classical monocyte: 2,190 nTPM
intermediate monocyte: 1,404 nTPM
total PBMC: 1,352 nTPM

Brain region

choroid plexus: 45 nTPM
cerebral cortex: 44 nTPM
hypothalamus: 39 nTPM
thalamus: 33 nTPM
medulla oblongata: 33 nTPM
pons: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.01
gnomAD missense Z: -0.31
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFITM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CD81

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFITM2 as an antibody target. Whether an autoantibody or antibody against IFITM2 could matter depends on whether native IFITM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFITM2 is annotated at the cell surface, where native IFITM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IFITM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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