Seroatlas · Human Serome Atlas

IFITM10

Interferon-induced transmembrane protein 10

Also known as: DSPA3, IFM10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMD0
Gene: IFITM10
Ensembl: ENSG00000244242
Chromosome: 11
Canonical length: 228 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>A6NMD0|IFITM10
     1  MREGKRGPPC ILSFRGTLER VEAQWELEAQ GPGQCPAPLG DPASTTDGAQ EARVPLDGAF
    61  WIPRPPAGSP KGCFACVSKP PALQAPAAPA PEPSASPPMA PTLFPMESKS SKTDSVRAAG
   121  APPACKHLAE KKTMTNPTTV IEVYPDTTEV NDYYLWSIFN FVYLNFCCLG FIALAYSLKV
   181  RDKKLLNDLN GAVEDAKTAR LFNITSSALA ASCIILVFIF LRYPLTDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFITM10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 2.4 nTPM
bone marrow: 1.4 nTPM
retina: 1.3 nTPM
cerebral cortex: 0.8 nTPM
cerebellum: 0.7 nTPM
blood vessel: 0.5 nTPM

Single-cell type

oligodendrocyte progenitor cells: 31 nCPM
other brain neurons: 11 nCPM
brain excitatory neurons: 9.9 nCPM
brain inhibitory neurons: 8 nCPM
microglia: 6.8 nCPM
papillary tip epithelial cells: 3.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3 nTPM
pons: 1.3 nTPM
hypothalamus: 1.2 nTPM
medulla oblongata: 1.2 nTPM
thalamus: 1.1 nTPM
cerebral cortex: 1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFITM10.

Disease | ImmuneIEDB

Conditions an epitope on IFITM10 was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0.16
gnomAD missense Z: 0.9
DepMap mean gene effect: -0.01
DepMap dependency class: none

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFITM10 as an antibody target. Whether an autoantibody or antibody against IFITM10 could matter depends on whether native IFITM10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFITM10 is annotated at the cell surface, where native IFITM10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IFITM10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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