Seroatlas · Human Serome Atlas

IFFO2

Intermediate filament family orphan 2

Also known as: IFFO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TF58
Gene: IFFO2
Ensembl: ENSG00000169991
Chromosome: 1
Canonical length: 517 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q5TF58|IFFO2
     1  MVNSLLFGEM ALAFGCPPGG GGGGCPGGGG GGGGAGPGPS PVTAALRDDL GSNIHLLKGL
    61  NVRFRCFLAK VHELERRNRL LEKQLEQQQS ERERRLRYKT FSREQAVQTG PELLRPPAPG
   121  GGHGLSSGAA AGANANAVAL GGLPPGGGSH PQHYGRLPGT IWSYTQVRRT GGGGVETVQG
   181  PGVSWVHPDG VGVQIDTITP EIRALYNVLA KVKRERDEYK RRWEEELAKR MNLQTMVDTL
   241  QEAAQEADAI QEEMNEKIER LKAELVVFKG LMSDPMTDLD TKIQEKAMKV DMDICRRIDI
   301  TAKLCDVAQQ RNSEDVSKIF QVVPKKKERK VASDDDISEQ DGEVNRFSDD EVGSMNITDE
   361  MKRMFNQLRE TFDFDDDCDS LTWEENEDTL LLWEDFTNCN PTIDLQGEQE ENLGNLIHET
   421  ESFFKTRDKE YQETIGQIEL ELATAKSDMN RHLHEYMEMC SMKRGLDVQM ETCRRLIKGS
   481  ADRNSPSPSS VASSDSGSTD EIQDEFEREA DVEPMVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFFO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 161 nTPM

Expression across tissuesHPA

Tissue

skin: 161 nTPM
esophagus: 40 nTPM
cerebellum: 27 nTPM
vagina: 20 nTPM
pancreas: 18 nTPM
cervix: 15 nTPM

Single-cell type

esophageal apical cells: 376 nCPM
basal keratinocytes: 261 nCPM
suprabasal keratinocytes: 215 nCPM
salivary myoepithelial cells: 187 nCPM
respiratory basal cells: 183 nCPM
esophageal suprabasal cells: 158 nCPM

Immune cell

basophil: 13 nTPM
naive CD8 T-cell: 0.6 nTPM
MAIT T-cell: 0.5 nTPM
memory B-cell: 0.5 nTPM
gdT-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM

Brain region

cerebellum: 49 nTPM
medulla oblongata: 32 nTPM
cerebral cortex: 30 nTPM
pons: 29 nTPM
thalamus: 29 nTPM
midbrain: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFFO2.

Disease | ImmuneIEDB

Conditions an epitope on IFFO2 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.73
gnomAD missense Z: 2.49
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

intermediate filament

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFFO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFFO2 as an antibody target. Whether an autoantibody or antibody against IFFO2 could matter depends on whether native IFFO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFFO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFFO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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