Seroatlas · Human Serome Atlas

IFFO1

Non-homologous end joining factor IFFO1

Also known as: HOM-TES-103, IFFO, IFFO1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0D2I5
Gene: IFFO1
Ensembl: ENSG00000010295
Chromosome: 12
Canonical length: 559 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q0D2I5|IFFO1
     1  MNPLFGPNLF LLQQEQQGLA GPLGDSLGGD HFAGGGDLPP APLSPAGPAA YSPPGPGPAP
    61  PAAMALRNDL GSNINVLKTL NLRFRCFLAK VHELERRNRL LEKQLQQALE EGKQGRRGLG
   121  RRDQAVQTGF VSPIRPLGLQ LGARPAAVCS PSARVLGSPA RSPAGPLAPS AASLSSSSTS
   181  TSTTYSSSAR FMPGTIWSFS HARRLGPGLE PTLVQGPGLS WVHPDGVGVQ IDTITPEIRA
   241  LYNVLAKVKR ERDEYKRRWE EEYTVRIQLQ DRVNELQEEA QEADACQEEL ALKVEQLKAE
   301  LVVFKGLMSN NLSELDTKIQ EKAMKVDMDI CRRIDITAKL CDVAQQRNCE DMIQMFQVPS
   361  MGGRKRERKA AVEEDTSLSE SEGPRQPDGD EEESTALSIN EEMQRMLNQL REYDFEDDCD
   421  SLTWEETEET LLLWEDFSGY AMAAAEAQGE QEDSLEKVIK DTESLFKTRE KEYQETIDQI
   481  ELELATAKND MNRHLHEYME MCSMKRGLDV QMETCRRLIT QSGDRKSPAF TAVPLSDPPP
   541  PPSEAEDSDR DVSSDSSMR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFFO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 16 nTPM
cerebellum: 16 nTPM
cerebral cortex: 11 nTPM
spleen: 11 nTPM
endometrium: 11 nTPM
skeletal muscle: 10 nTPM

Single-cell type

microglia: 44 nCPM
sertoli cells: 35 nCPM
fibro-adipogenic progenitors: 31 nCPM
hofbauer cells: 30 nCPM
macrophages: 28 nCPM
leydig cells: 26 nCPM

Immune cell

non-classical monocyte: 6.7 nTPM
classical monocyte: 4.8 nTPM
intermediate monocyte: 3.3 nTPM
myeloid DC: 3.1 nTPM
eosinophil: 2.8 nTPM
NK-cell: 2.7 nTPM

Brain region

cerebral cortex: 27 nTPM
white matter: 19 nTPM
pons: 18 nTPM
thalamus: 17 nTPM
hypothalamus: 17 nTPM
medulla oblongata: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFFO1.

Disease | ImmuneIEDB

Conditions an epitope on IFFO1 was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytoskeletal anchor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Intermediate filament, rod domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFFO1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFFO1 as an antibody target. Whether an autoantibody or antibody against IFFO1 could matter depends on whether native IFFO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFFO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFFO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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