Seroatlas · Human Serome Atlas

ICAM4

Intercellular adhesion molecule 4

Also known as: CD242, ICAM4_HUMAN, LW

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14773
Gene: ICAM4
Ensembl: ENSG00000105371
Chromosome: 19
Canonical length: 271 aa
Protein class: Blood group antigen proteins, CD markers, Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q14773|ICAM4
     1  MGSLFPLSLL FFLAAAYPGV GSALGRRTKR AQSPKGSPLA PSGTSVPFWV RMSPEFVAVQ
    61  PGKSVQLNCS NSCPQPQNSS LRTPLRQGKT LRGPGWVSYQ LLDVRAWSSL AHCLVTCAGK
   121  TRWATSRITA YKPPHSVILE PPVLKGRKYT LRCHVTQVFP VGYLVVTLRH GSRVIYSESL
   181  ERFTGLDLAN VTLTYEFAAG PRDFWQPVIC HARLNLDGLV VRNSSAPITL MLAWSPAPTA
   241  LASGSIAALV GILLTVGAAY LCKCLAMKSQ A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ICAM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 13 nTPM
lung: 8.7 nTPM
placenta: 1.6 nTPM
urinary bladder: 1.6 nTPM
stomach: 1.4 nTPM
tonsil: 1.3 nTPM

Single-cell type

alveolar cells type 2: 76 nCPM
transitional alveolar cells: 71 nCPM
megakaryocyte-erythroid progenitors: 37 nCPM
neutrophils: 33 nCPM
megakaryocytes: 31 nCPM
erythrocyte progenitors: 31 nCPM

Immune cell

non-classical monocyte: 216 nTPM
intermediate monocyte: 39 nTPM
myeloid DC: 31 nTPM
basophil: 24 nTPM
eosinophil: 10 nTPM
plasmacytoid DC: 10 nTPM

Brain region

cerebral cortex: 9.1 nTPM
basal ganglia: 7.5 nTPM
white matter: 7.5 nTPM
hippocampal formation: 7.4 nTPM
cerebellum: 7.2 nTPM
amygdala: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ICAM4 as an antibody target. Whether an autoantibody or antibody against ICAM4 could matter depends on whether native ICAM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ICAM4 is annotated at the cell surface, where native ICAM4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ICAM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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