Seroatlas · Human Serome Atlas

HTR3E

5-hydroxytryptamine receptor 3E

Also known as: 5HT3E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5X5Y0
Gene: HTR3E
Ensembl: ENSG00000186038
Chromosome: 3
Canonical length: 456 aa
Protein class: FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>A5X5Y0|HTR3E
     1  MEGSWFHRKR FSFYLLLGFL LQGRGVTFTI NCSGFGQHGA DPTALNSVFN RKPFRPVTNI
    61  SVPTQVNISF AMSAILDVNE QLHLLSSFLW LEMVWDNPFI SWNPEECEGI TKMSMAAKNL
   121  WLPDIFIIEL MDVDKTPKGL TAYVSNEGRI RYKKPMKVDS ICNLDIFYFP FDQQNCTLTF
   181  SSFLYTVDSM LLDMEKEVWE ITDASRNILQ THGEWELLGL SKATAKLSRG GNLYDQIVFY
   241  VAIRRRPSLY VINLLVPSGF LVAIDALSFY LPVKSGNRVP FKITLLLGYN VFLLMMSDLL
   301  PTSGTPLIGV YFALCLSLMV GSLLETIFIT HLLHVATTQP PPLPRWLHSL LLHCNSPGRC
   361  CPTAPQKENK GPGLTPTHLP GVKEPEVSAG QMPGPAEAEL TGGSEWTRAQ REHEAQKQHS
   421  VELWLQFSHA MDAMLFRLYL LFMASSIITV ICLWNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTR3E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

duodenum: 0.9 nTPM
colon: 0.6 nTPM
small intestine: 0.6 nTPM
placenta: 0.2 nTPM
rectum: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

tuft cells: 438 nCPM
retinal ganglion cells: 7.7 nCPM
retinal horizontal cells: 4 nCPM
papillary tip epithelial cells: 2.7 nCPM
renal collecting duct principal cells: 2.3 nCPM
salivary ionocytes: 2.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1.5 nTPM
cerebral cortex: 1.4 nTPM
basal ganglia: 1.2 nTPM
pons: 1.2 nTPM
amygdala: 1.1 nTPM
medulla oblongata: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -0.51
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTR3E as an antibody target. Whether an autoantibody or antibody against HTR3E could matter depends on whether native HTR3E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTR3E is annotated at the cell surface, where native HTR3E is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HTR3E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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