Seroatlas · Human Serome Atlas

HTR3C

5-hydroxytryptamine receptor 3C

Also known as: 5HT3C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXA8
Gene: HTR3C
Ensembl: ENSG00000178084
Chromosome: 3
Canonical length: 447 aa
Protein class: FDA approved drug targets, Predicted membrane proteins

OverviewNCBI Gene

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q8WXA8|HTR3C
     1  MEGGWPARQS ALLCLTVSLL LQGRGDAFTI NCSGFDQHGV DPAVFQAVFD RKAFRPFTNY
    61  SIPTRVNISF TLSAILGVDA QLQLLTSFLW MDLVWDNPFI NWNPKECVGI NKLTVLAENL
   121  WLPDIFIVES MDVDQTPSGL TAYISSEGRI KYDKPMRVTS ICNLDIFYFP FDQQNCTFTF
   181  SSFLYTVDSM LLGMDKEVWE ITDTSRKVIQ TQGEWELLGI NKATPKMSMG NNLYDQIMFY
   241  VAIRRRPSLY IINLLVPSSF LVAIDALSFY LPAESENRAP FKITLLLGYN VFLLMMNDLL
   301  PASGTPLISV YFALCLSLMV VSLLETVFIT YLLHVATTQP PPMPRWLHSL LLHCTSPGRC
   361  CPTAPQKGNK GLGLTLTHLP GPKEPGELAG KKLGPRETEP DGGSGWTKTQ LMELWVQFSH
   421  AMDTLLFRLY LLFMASSILT VIVLWNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTR3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 2.3 nTPM

Expression across tissuesHPA

Tissue

lung: 2.3 nTPM
duodenum: 0.4 nTPM
colon: 0.3 nTPM
small intestine: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

tuft cells: 185 nCPM
oocytes: 4.6 nCPM
lymphatic endothelial cells: 3 nCPM
platelets: 1.4 nCPM
early spermatids: 1.2 nCPM
prostatic hillock cells: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
white matter: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM
pons: 0.2 nTPM
cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTR3C as an antibody target. Whether an autoantibody or antibody against HTR3C could matter depends on whether native HTR3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTR3C is annotated at the cell surface, where native HTR3C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HTR3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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