HPGDS

Protein identityUniProt · HPA

UniProt accession

O60760

Gene

HPGDS

Ensembl

ENSG00000163106

Chromosome

4

Canonical length

199 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Vesicles,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>O60760|HPGDS
     1  MPNYKLTYFN MRGRAEIIRY IFAYLDIQYE DHRIEQADWP EIKSTLPFGK IPILEVDGLT
    61  LHQSLAIARY LTKNTDLAGN TEMEQCHVDA IVDTLDDFMS CFPWAEKKQD VKEQMFNELL
   121  TYNAPHLMQD LDTYLGGREW LIGNSVTWAD FYWEICSTTL LVFKPDLLDN HPRLVTLRKK
   181  VQAIPAVANW IKRRPQTKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HPGDS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

18 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HPGDS.

Disease | AutoantibodyPubMed

Conditions in which antibodies against HPGDS are reported. Each links to that disease's full target list.

• Hepatitis, Autoimmune 7

ReferencesPubMed · IEDB

Publications for HPGDS from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.63

gnomAD pLI

0

gnomAD missense Z

-1.03

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cyclooxygenase pathway
• glutathione metabolic process
• locomotory behavior
• negative regulation of male germ cell proliferation
• prostaglandin metabolic process
• response to nematode
• response to selenium ion
• signal transduction

Molecular functions

• calcium ion binding
• glutathione transferase activity
• magnesium ion binding
• prostaglandin-D synthase activity
• protein homodimerization activity

Cellular components

• cytoplasm
• cytosol
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Glutathione S-transferase, N-terminal
• Glutathione S-transferase, C-terminal
• Glutathione S-transferase, C-terminal-like
• Thioredoxin-like superfamily
• Glutathione S-transferase, C-terminal domain superfamily
• Glutathione transferase family
• Glutathione S-transferase superfamily
• Glutathione S-transferase, N-terminal domain
• Glutathione S-transferase, C-terminal domain

KeywordsUniProt

• Calcium
• Cytoplasm
• Fatty acid biosynthesis
• Fatty acid metabolism
• Isomerase
• Lipid biosynthesis
• Lipid metabolism
• Magnesium
• Metal-binding
• Prostaglandin biosynthesis
• Prostaglandin metabolism
• Transferase