Seroatlas · Human Serome Atlas

HPF1

Histone PARylation factor 1

Also known as: C4orf27, FLJ20534, HPF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWY4
Gene: HPF1
Ensembl: ENSG00000056050
Chromosome: 4
Canonical length: 346 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Enables chromatin binding activity; histone binding activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Involved in DNA repair-dependent chromatin remodeling and double-strand break repair. Located in chromatin and nucleus. Is active in site of DNA damage. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q9NWY4|HPF1
     1  MVGGGGKRRP GGEGPQCEKT TDVKKSKFCE ADVSSDLRKE VENHYKLSLP EDFYHFWKFC
    61  EELDPEKPSD SLSASLGLQL VGPYDILAGK HKTKKKSTGL NFNLHWRFYY DPPEFQTIII
   121  GDNKTQYHMG YFRDSPDEFP VYVGINEAKK NCIIVPNGDN VFAAVKLFLT KKLREITDKK
   181  KINLLKNIDE KLTEAARELG YSLEQRTVKM KQRDKKVVTK TFHGAGLVVP VDKNDVGYRE
   241  LPETDADLKR ICKTIVEAAS DEERLKAFAP IQEMMTFVQF ANDECDYGMG LELGMDLFCY
   301  GSHYFHKVAG QLLPLAYNLL KRNLFAEIIE EHLANRSQEN IDQLAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HPF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 29 nTPM
amygdala: 27 nTPM
ovary: 27 nTPM
spinal cord: 27 nTPM
hippocampal formation: 27 nTPM
choroid plexus: 27 nTPM

Single-cell type

oocytes: 304 nCPM
erythrocyte progenitors: 88 nCPM
cytotrophoblasts: 87 nCPM
hofbauer cells: 84 nCPM
extravillous trophoblasts: 78 nCPM
esophageal basal cells: 73 nCPM

Immune cell

T-reg: 38 nTPM
memory CD8 T-cell: 35 nTPM
MAIT T-cell: 35 nTPM
naive CD8 T-cell: 33 nTPM
memory CD4 T-cell: 33 nTPM
naive CD4 T-cell: 32 nTPM

Brain region

choroid plexus: 22 nTPM
white matter: 22 nTPM
pons: 19 nTPM
cerebral cortex: 18 nTPM
medulla oblongata: 18 nTPM
basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HPF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HPF1 as an antibody target. Whether an autoantibody or antibody against HPF1 could matter depends on whether native HPF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HPF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HPF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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