Seroatlas · Human Serome Atlas

HHIPL2

HHIP-like protein 2

Also known as: FLJ13840, HIPL2_HUMAN, KIAA1822L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWX4
Gene: HHIPL2
Ensembl: ENSG00000143512
Chromosome: 1
Canonical length: 724 aa
Protein class: Predicted secreted proteins
Subcellular location: Mitochondria,Cytosol
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

724 residues, UniProt reviewed canonical sequence.

>Q6UWX4|HHIPL2
     1  MLRTSTPNLC GGLHCRAPWL SSGILCLCLI FLLGQVGLLQ GHPQCLDYGP PFQPPLHLEF
    61  CSDYESFGCC DQHKDRRIAA RYWDIMEYFD LKRHELCGDY IKDILCQECS PYAAHLYDAE
   121  NTQTPLRNLP GLCSDYCSAF HSNCHSAISL LTNDRGLQES HGRDGTRFCH LLDLPDKDYC
   181  FPNVLRNDYL NRHLGMVAQD PQGCLQLCLS EVANGLRNPV SMVHAGDGTH RFFVAEQVGV
   241  VWVYLPDGSR LEQPFLDLKN IVLTTPWIGD ERGFLGLAFH PKFRHNRKFY IYYSCLDKKK
   301  VEKIRISEMK VSRADPNKAD LKSERVILEI EEPASNHNGG QLLFGLDGYM YIFTGDGGQA
   361  GDPFGLFGNA QNKSSLLGKV LRIDVNRAGS HGKRYRVPSD NPFVSEPGAH PAIYAYGIRN
   421  MWRCAVDRGD PITRQGRGRI FCGDVGQNRF EEVDLILKGG NYGWRAKEGF ACYDKKLCHN
   481  ASLDDVLPIY AYGHAVGKSV TGGYVYRGCE SPNLNGLYIF GDFMSGRLMA LQEDRKNKKW
   541  KKQDLCLGST TSCAFPGLIS THSKFIISFA EDEAGELYFL ATSYPSAYAP RGSIYKFVDP
   601  SRRAPPGKCK YKPVPVRTKS KRIPFRPLAK TVLDLLKEQS EKAARKSSSA TLASGPAQGL
   661  SEKGSSKKLA SPTSSKNTLR GPGTKKKARV GPHVRQGKRR KSLKSHSGRM RPSAEQKRAG
   721  RSLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HHIPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 4.5 nTPM

Expression across tissuesHPA

Tissue

testis: 4.5 nTPM
thyroid gland: 1.9 nTPM
salivary gland: 1 nTPM
prostate: 0.7 nTPM
adrenal gland: 0.3 nTPM
adipose tissue: 0.2 nTPM

Single-cell type

late spermatids: 42 nCPM
late primary spermatocytes: 34 nCPM
early spermatids: 24 nCPM
breast lactating cells: 6.9 nCPM
early primary spermatocytes: 5.5 nCPM
epicardial cells: 2.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.5 nTPM
hypothalamus: 0.3 nTPM
medulla oblongata: 0.3 nTPM
basal ganglia: 0.2 nTPM
choroid plexus: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HHIPL2 as an antibody target. Whether an autoantibody or antibody against HHIPL2 could matter depends on whether native HHIPL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HHIPL2 is annotated as secreted, so native HHIPL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HHIPL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...