Seroatlas · Human Serome Atlas

HHIPL1

HHIP-like protein 1

Also known as: HIPL1_HUMAN, KIAA1822

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96JK4
Gene
HHIPL1
Ensembl
ENSG00000182218
Chromosome
14
Canonical length
782 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes a protein that belongs to the glucose/sorbosone dehydrogenase family. The encoded protein also contains a domain that binds folate and reduced folic acid derivatives. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

782 residues, UniProt reviewed canonical sequence.

>Q96JK4|HHIPL1
     1  MARARAGALL ALWVLGAAAH PQCLDFRPPF RPTQPLRLCA QYSDFGCCDE GRDAELTRRF
    61  WALASRVDAA EWAACAGYAR DLLCQECSPY AAHLYDAEDP FTPLRTVPGL CQDYCLDMWH
   121  KCRGLFRHLS TDQELWALEG NLARFCRYLS LDDTDYCFPY LLVNKNLNSN LGHVVADAKG
   181  CLQLCLEEVA NGLRNPVAMV HARDGTHRFF VAEQVGLVWA YLPDRSRLGK PFLNISRVVL
   241  TSPWEGDERG FLGIAFHPSF QHNRRLYVYY SVGIRSSEWI RISEFRVSED DENAVDHSSE
   301  RIILEVKEPA SNHNGGQLLF GDDGYLYIFT GDGGMAGDPF GTFGNAQNKS ALLGKVLRID
   361  VDRKERGLPY GIPPDNPFVG DPAAQPEVYA LGVRNMWRCS FDRGDPSSGT GRGRLFCGDV
   421  GQNKFEEVDV VERGGNYGWR AREGFECYDR SLCANTSLND LLPIFAYPHT VGKSVTGGYV
   481  YRGCEYPNLN GLYIFGDFMS GRLMSLQENP GTGQWQYSEI CMGHGQTCEF PGLINNYYPY
   541  IISFGEDEAG ELYFMSTGEP SATAPRGVVY KIIDASRRAP PGKCQIQPAQ VKIRSRLIPF
   601  VPKEKFIPKT RSTPRPTARA PTRAPRRGRP TAAPPAPTPR PARPTQQPGS RRGGGRRRGR
   661  LNSASRAFRD GEVRLVRPAG LSSGSGRVEV FVGGRWGTVC DDSWNISGAA VVCRQLGFAY
   721  AVRAVKRAEF GQGGSLPILL DDVRCAGWER NLLECQHNGV GTHNCEHDED AGVVCSHQNP
   781  DL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HHIPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
9.5 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 9.5 nTPM
  • cerebral cortex: 8 nTPM
  • amygdala: 7.3 nTPM
  • hippocampal formation: 5.3 nTPM
  • cerebellum: 3.3 nTPM
  • hypothalamus: 3.3 nTPM

Single-cell type

  • astrocytes: 39 nCPM
  • retinal amacrine cells: 28 nCPM
  • müller glia: 23 nCPM
  • bergmann glia: 21 nCPM
  • retinal bipolar cells: 19 nCPM
  • mesothelial cells: 14 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 22 nTPM
  • cerebral cortex: 21 nTPM
  • hippocampal formation: 19 nTPM
  • amygdala: 18 nTPM
  • thalamus: 17 nTPM
  • medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
1.59
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HHIPL1 as an antibody target. Whether an autoantibody or antibody against HHIPL1 could matter depends on whether native HHIPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HHIPL1 is annotated as secreted, so native HHIPL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HHIPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HHIPL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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