Seroatlas · Human Serome Atlas

HEMGN

Hemogen

Also known as: CT155, EDAG, HEMGN_HUMAN, NDR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXL5
Gene: HEMGN
Ensembl: ENSG00000136929
Chromosome: 9
Canonical length: 484 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in regulation of osteoblast differentiation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

484 residues, UniProt reviewed canonical sequence.

>Q9BXL5|HEMGN
     1  MDLGKDQSHL KHHQTPDPHQ EENHSPEVIG TWSLRNRELL RKRKAEVHEK ETSQWLFGEQ
    61  KKRKQQRTGK GNRRGRKRQQ NTELKVEPQP QIEKEIVEKA LAPIEKKTEP PGSITKVFPS
   121  VASPQKVVPE EHFSEICQES NIYQENFSEY QEIAVQNHSS ETCQHVSEPE DLSPKMYQEI
   181  SVLQDNSSKI CQDMKEPEDN SPNTCQVISV IQDHPFKMYQ DMAKREDLAP KMCQEAAVPK
   241  ILPCPTSEDT ADLAGCSLQA YPKPDVPKGY ILDTDQNPAE PEEYNETDQG IAETEGLFPK
   301  IQEIAEPKDL STKTHQESAE PKYLPHKTCN EIIVPKAPSH KTIQETPHSE DYSIEINQET
   361  PGSEKYSPET YQEIPGLEEY SPEIYQETSQ LEEYSPEIYQ ETPGPEDLST ETYKNKDVPK
   421  ECFPEPHQET GGPQGQDPKA HQEDAKDAYT FPQEMKEKPK EEPGIPAILN ESHPENDVYS
   481  YVLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HEMGN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 233 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 233 nTPM
testis: 47 nTPM
thymus: 12 nTPM
placenta: 5.6 nTPM
spleen: 3.1 nTPM
lymph node: 1.4 nTPM

Single-cell type

late spermatids: 2,278 nCPM
early spermatids: 1,790 nCPM
erythrocyte progenitors: 545 nCPM
megakaryocytes: 464 nCPM
platelets: 412 nCPM
erythrocytes: 327 nCPM

Immune cell

naive CD4 T-cell: 5.1 nTPM
total PBMC: 2.7 nTPM
basophil: 2.2 nTPM
naive CD8 T-cell: 2.1 nTPM
NK-cell: 2 nTPM
memory CD4 T-cell: 1.5 nTPM

Brain region

white matter: 3.3 nTPM
medulla oblongata: 2.9 nTPM
cerebellum: 2.6 nTPM
cerebral cortex: 2.6 nTPM
pons: 2.4 nTPM
amygdala: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

Hemogen

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HEMGN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HEMGN as an antibody target. Whether an autoantibody or antibody against HEMGN could matter depends on whether native HEMGN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HEMGN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HEMGN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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