Seroatlas · Human Serome Atlas

HDX

Highly divergent homeobox

Also known as: CXorf43, FLJ30678, HDX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z353
Gene
HDX
Ensembl
ENSG00000165259
Chromosome
X
Canonical length
690 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

690 residues, UniProt reviewed canonical sequence.

>Q7Z353|HDX
     1  MNLRSVFTVE QQRILQRYYE NGMTNQSKNC FQLILQCAQE TKLDFSVVRT WVGNKRRKMS
    61  SKNSESGTAT TGTSLSAPDI TVRNVVNIAR PSSQQSSWTS ANNDVIVTGI YSPASSSSRQ
   121  GTNKHTDTQI TEAHKIPIQK TATKNDTEFQ LHIPVQRQVA HCKNASLLLG EKTIILSRQT
   181  SVLNAGNSVF NHAKKNYGNS SVQASEMTVP QKPSVCHRPC KIEPVGIQRS YKPEHTGPAL
   241  HNLCGQKPTI RDPYCRTQNL EIREVFSLAV SDYPQRILGG NAPQKPSSAE GNCLSIAMET
   301  GDAEDEYARE EELASMRAQI PSYSRFYESG SSLRAENQST TLPGPGRNMP NSQMVNIRDM
   361  SDNVLYQNRN YHLTPRTSLH TASSTMYSNT NPLRSNFSPH FASSNQLRLS QNQNNYQISG
   421  NLTVPWITGC SRKRALQDRT QFSDRDLATL KKYWDNGMTS LGSVCREKIE AVATELNVDC
   481  EIVRTWIGNR RRKYRLMGIE VPPPRGGPAD FSEQPESGSL SALTPGEEAG PEVGEDNDRN
   541  DEVSICLSEG SSQEEPNEVV PNDARAHKEE DHHAVTTDNV KIEIIDDEES DMISNSEVEQ
   601  VNSFLDYKNE EVKFIENELE IQKQKYFKLQ TFVRSLILAM KADDKEQQQA LLSDLPPELE
   661  EMDFNHASLE PDDTSFSVSS LSEKNVSESL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
2.6 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 2.6 nTPM
  • cerebral cortex: 1.8 nTPM
  • cerebellum: 1.7 nTPM
  • cervix: 1.7 nTPM
  • endometrium: 1.7 nTPM
  • ovary: 1.7 nTPM

Single-cell type

  • epididymal basal cells: 174 nCPM
  • urothelial cells: 125 nCPM
  • gonadotrophs: 102 nCPM
  • pancreatic duct cells: 98 nCPM
  • ocular epithelial cells: 84 nCPM
  • somatotrophs: 73 nCPM

Immune cell

  • non-classical monocyte: 3.6 nTPM
  • intermediate monocyte: 3.5 nTPM
  • myeloid DC: 3.2 nTPM
  • classical monocyte: 2.3 nTPM
  • memory B-cell: 1.8 nTPM
  • NK-cell: 0.9 nTPM

Brain region

  • cerebellum: 9.5 nTPM
  • cerebral cortex: 6.7 nTPM
  • hypothalamus: 6 nTPM
  • white matter: 6 nTPM
  • medulla oblongata: 5.7 nTPM
  • pons: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.08
gnomAD missense Z
0.13
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HDX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDX as an antibody target. Whether an autoantibody or antibody against HDX could matter depends on whether native HDX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HDX. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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