Seroatlas · Human Serome Atlas

HDDC2

5'-deoxynucleotidase HDDC2

Also known as: C6orf74, CGI-130, dJ167O5.2, HDDC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4H3
Gene: HDDC2
Ensembl: ENSG00000111906
Chromosome: 6
Canonical length: 204 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable 5'-deoxynucleotidase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q7Z4H3|HDDC2
     1  MASVSSATFS GHGARSLLQF LRLVGQLKRV PRTGWVYRNV QRPESVSDHM YRMAVMAMVI
    61  KDDRLNKDRC VRLALVHDMA ECIVGDIAPA DNIPKEEKHR REEEAMKQIT QLLPEDLRKE
   121  LYELWEEYET QSSAEAKFVK QLDQCEMILQ ASEYEDLEHK PGRLQDFYDS TAGKFNHPEI
   181  VQLVSELEAE RSTNIAAAAS EPHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 157 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 157 nTPM
amygdala: 111 nTPM
midbrain: 97 nTPM
cerebral cortex: 94 nTPM
hippocampal formation: 93 nTPM
hypothalamus: 86 nTPM

Single-cell type

cardiomyocytes: 334 nCPM
myonuclei: 266 nCPM
esophageal suprabasal cells: 229 nCPM
esophageal basal cells: 225 nCPM
parietal cells: 200 nCPM
extravillous trophoblasts: 197 nCPM

Immune cell

naive CD8 T-cell: 78 nTPM
memory CD8 T-cell: 73 nTPM
memory B-cell: 72 nTPM
naive CD4 T-cell: 72 nTPM
NK-cell: 62 nTPM
naive B-cell: 60 nTPM

Brain region

choroid plexus: 82 nTPM
midbrain: 57 nTPM
basal ganglia: 55 nTPM
medulla oblongata: 54 nTPM
hypothalamus: 52 nTPM
pons: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

deoxyribonucleoside monophosphate catabolic process

Molecular functions

Protein domainsUniProt · Pfam · InterPro

HD/PDEase domain
HD domain
5'-deoxynucleotidase YfbR/HDDC2
HD domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDDC2 as an antibody target. Whether an autoantibody or antibody against HDDC2 could matter depends on whether native HDDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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