GYG2

Protein identityUniProt · HPA

UniProt accession

O15488

Gene

GYG2

Ensembl

ENSG00000056998

Chromosome

X

Canonical length

501 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the the glycogenin family. Glycogenin is a self-glucosylating protein involved in the initiation reactions of glycogen biosynthesis. A gene on chromosome 3 encodes the muscle glycogenin and this X-linked gene encodes the glycogenin mainly present in liver; both are involved in blood glucose homeostasis. This gene has a short version on chromosome Y, which is 3' truncated and can not make a functional protein. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>O15488|GYG2
     1  MSETEFHHGA QAGLELLRSS NSPTSASQSA GMTVTDQAFV TLATNDIYCQ GALVLGQSLR
    61  RHRLTRKLVV LITPQVSSLL RVILSKVFDE VIEVNLIDSA DYIHLAFLKR PELGLTLTKL
   121  HCWTLTHYSK CVFLDADTLV LSNVDELFDR GEFSAAPDPG WPDCFNSGVF VFQPSLHTHK
   181  LLLQHAMEHG SFDGADQGLL NSFFRNWSTT DIHKHLPFIY NLSSNTMYTY SPAFKQFGSS
   241  AKVVHFLGSM KPWNYKYNPQ SGSVLEQGSA SSSQHQAAFL HLWWTVYQNN VLPLYKSVQA
   301  GEARASPGHT LCHSDVGGPC ADSASGVGEP CENSTPSAGV PCANSPLGSN QPAQGLPEPT
   361  QIVDETLSLP EGRRSEDMIA CPETETPAVI TCDPLSQPSP QPADFTETET ILQPANKVES
   421  VSSEETFEPS QELPAEALRD PSLQDALEVD LAVSVSQISI EEKVKELSPE EERRKWEEGR
   481  IDYMGKDAFA RIQEKLDRFL Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GYG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

147 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.57

gnomAD pLI

0

gnomAD missense Z

0.08

DepMap mean gene effect

0.21

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• glycogen biosynthetic process

Molecular functions

• glycogenin glucosyltransferase activity
• glycosyltransferase activity
• metal ion binding

Cellular components

• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Glycosyl transferase, family 8
• Nucleotide-diphospho-sugar transferases
• GNT1/Glycosyltransferase 8
• Glycosyl transferase family 8

KeywordsUniProt

• Cytoplasm
• Glycogen biosynthesis
• Glycoprotein
• Manganese
• Metal-binding
• Nucleus
• Phosphoprotein
• Transferase

InteractionsUniProt · HPA

Protein binding partners of GYG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GYG1
• GYS1
• GYS2