Seroatlas · Human Serome Atlas

GYG1

Glycogenin-1

Also known as: GLYG_HUMAN, GYG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46976
Gene
GYG1
Ensembl
ENSG00000163754
Chromosome
3
Canonical length
350 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>P46976|GYG1
     1  MTDQAFVTLT TNDAYAKGAL VLGSSLKQHR TTRRLVVLAT PQVSDSMRKV LETVFDEVIM
    61  VDVLDSGDSA HLTLMKRPEL GVTLTKLHCW SLTQYSKCVF MDADTLVLAN IDDLFDREEL
   121  SAAPDPGWPD CFNSGVFVYQ PSVETYNQLL HLASEQGSFD GGDQGILNTF FSSWATTDIR
   181  KHLPFIYNLS SISIYSYLPA FKVFGASAKV VHFLGRVKPW NYTYDPKTKS VKSEAHDPNM
   241  THPEFLILWW NIFTTNVLPL LQQFGLVKDT CSYVNVLSDL VYTLAFSCGF CRKEDVSGAI
   301  SHLSLGEIPA MAQPFVSSEE RKERWEQGQA DYMGADSFDN IKRKLDTYLQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GYG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
535 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 535 nTPM
  • tongue: 334 nTPM
  • bone marrow: 208 nTPM
  • colon: 142 nTPM
  • heart muscle: 110 nTPM
  • testis: 108 nTPM

Single-cell type

  • oocytes: 1,202 nCPM
  • late spermatids: 618 nCPM
  • late primary spermatocytes: 610 nCPM
  • neutrophils: 609 nCPM
  • neutrophil progenitors: 584 nCPM
  • early spermatids: 206 nCPM

Immune cell

  • MAIT T-cell: 73 nTPM
  • non-classical monocyte: 68 nTPM
  • myeloid DC: 64 nTPM
  • intermediate monocyte: 60 nTPM
  • classical monocyte: 58 nTPM
  • total PBMC: 50 nTPM

Brain region

  • hypothalamus: 57 nTPM
  • midbrain: 47 nTPM
  • pons: 46 nTPM
  • white matter: 44 nTPM
  • medulla oblongata: 41 nTPM
  • spinal cord: 39 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GYG1.

Disease | AllUniProt

Conditions GYG1 is implicated in, by any mechanism.

Disease | GeneticClinVar

40 pathogenic / likely-pathogenic of 365 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
0.06
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GYG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GYG1 as an antibody target. Whether an autoantibody or antibody against GYG1 could matter depends on whether native GYG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GYG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GYG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GYG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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