GSTZ1

Protein identityUniProt · HPA

UniProt accession

O43708

Gene

GSTZ1

Ensembl

ENSG00000100577

Chromosome

14

Canonical length

216 aa

Protein class

Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>O43708|GSTZ1
     1  MQAGKPILYS YFRSSCSWRV RIALALKGID YKTVPINLIK DRGQQFSKDF QALNPMKQVP
    61  TLKIDGITIH QSLAIIEYLE EMRPTPRLLP QDPKKRASVR MISDLIAGGI QPLQNLSVLK
   121  QVGEEMQLTW AQNAITCGFN ALEQILQSTA GIYCVGDEVT MADLCLVPQV ANAERFKVDL
   181  TPYPTISSIN KRLLVLEAFQ VSHPCRQPDT PTELRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSTZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

246 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GSTZ1.

Disease | AllUniProt

Conditions GSTZ1 is implicated in, by any mechanism.

• Maleylacetoacetate isomerase deficiency (MAAID) MIM:617596

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 59 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Maleylacetoacetate isomerase deficiency
• GSTZ1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.48

gnomAD pLI

0

gnomAD missense Z

-0.01

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular detoxification
• glutathione metabolic process
• L-phenylalanine catabolic process
• L-tyrosine catabolic process

Molecular functions

• glutathione peroxidase activity
• glutathione transferase activity
• identical protein binding
• protein homodimerization activity
• maleylacetoacetate isomerase activity

Cellular components

• cytosol
• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Glutathione S-transferase, N-terminal
• Glutathione S-transferase, C-terminal
• Glutathione S-transferase, C-terminal-like
• Thioredoxin-like superfamily
• Glutathione S-transferase, C-terminal domain superfamily
• Glutathione transferase family
• Glutathione S-transferase, N-terminal domain
• Glutathione S-transferase, C-terminal domain
• Glutathione S-transferases, class Zeta
• Glutathione S-transferases, class Zeta , C-terminal
• Glutathione S-transferases, class Zeta , N-terminal

KeywordsUniProt

• Acetylation
• Cytoplasm
• Isomerase
• Multifunctional enzyme
• Phenylalanine catabolism
• Phosphoprotein
• Transferase
• Tyrosine catabolism