GSTT4
Glutathione S-transferase theta-4
Also known as: GSTT4_HUMAN, GSTTP1, HS322B1A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A1W2PR19
- Gene
- GSTT4
- Ensembl
- ENSG00000276950
- Chromosome
- 22
- Canonical length
- 241 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
241 residues, UniProt reviewed canonical sequence.
>A0A1W2PR19|GSTT4
1 MALELYMDLL SAPCRAVYIF SKKHDIQFNF QFVDLLKGHH HSKGYIDINP LRKLPSLKDG
61 KFILSESAAI LYYLCRKYSA PSHWCPPDPH ARARVDEFVA WQHTAFQLPM KKIVWLKLLI
121 PKITGEEVSA EKMEHAVEEV KNSLQLFEEY FLQDKMFITG NQISLADLVA VVEMMQPMAA
181 NYNVFLNSSK LAEWRMQVEL NIGSGLFREA HDRLMQLADW DFSTLDSMVK ENISELLKKS
241 RLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GSTT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 3.6 nTPM
Expression across tissuesHPA
Tissue
- testis: 3.6 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- early spermatids: 236 nCPM
- late spermatids: 206 nCPM
- late primary spermatocytes: 106 nCPM
- sertoli cells: 1.7 nCPM
- leydig cells: 0.5 nCPM
- epididymal efferent duct ciliated cells: 0.4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- amygdala: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Glutathione S-transferase, N-terminal
- Glutathione S-transferase, C-terminal
- Glutathione S-transferase, C-terminal-like
- Thioredoxin-like superfamily
- Glutathione S-transferase, C-terminal domain superfamily
- Glutathione S-transferase Theta, C-terminal
- Glutathione transferase family
- Glutathione S-transferase Theta
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GSTT4 as an antibody target. Whether an autoantibody or antibody against GSTT4 could matter depends on whether native GSTT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GSTT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GSTT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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