Seroatlas · Human Serome Atlas

GSTT2B

Glutathione S-transferase theta-2B

Also known as: GSTT2_HUMAN, GSTT2P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG30
Gene: GSTT2B
Ensembl: ENSG00000133433
Chromosome: 22
Canonical length: 244 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>P0CG30|GSTT2B
     1  MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS LGKLPTLKDG
    61  DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG WHADCIRGTF GIPLWVQVLG
   121  PLIGVQVPEE KVERNRTAMD QALQWLEDKF LGDRPFLAGQ QVTLADLMAL EELMQPVALG
   181  YELFEGRPRL AAWRGRVEAF LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI
   241  ARIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSTT2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 290 nTPM

Expression across tissuesHPA

Tissue

breast: 290 nTPM
adrenal gland: 79 nTPM
skin: 45 nTPM
tongue: 38 nTPM
prostate: 38 nTPM
liver: 38 nTPM

Single-cell type

loop of henle epithelial cells: 6.8 nCPM
renal collecting duct principal cells: 5.6 nCPM
papillary tip epithelial cells: 5.1 nCPM
renal connecting tubule cells: 5 nCPM
distal convoluted tubule cells: 4.4 nCPM
proximal tubule cells: 3.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 17 nTPM
hypothalamus: 17 nTPM
midbrain: 13 nTPM
medulla oblongata: 13 nTPM
amygdala: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.72
gnomAD missense Z: 0.72
DepMap mean gene effect: -0.16
DepMap dependency class: selective

OntologyGO

Biological processes

glutathione metabolic process

Molecular functions

glutathione transferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSTT2B as an antibody target. Whether an autoantibody or antibody against GSTT2B could matter depends on whether native GSTT2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSTT2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GSTT2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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