Seroatlas · Human Serome Atlas

GSTO2

Glutathione S-transferase omega-2

Also known as: GSTO2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4Y5
Gene: GSTO2
Ensembl: ENSG00000065621
Chromosome: 10
Canonical length: 243 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q9H4Y5|GSTO2
     1  MSGDATRTLG KGSQPPGPVP EGLIRIYSMR FCPYSHRTRL VLKAKDIRHE VVNINLRNKP
    61  EWYYTKHPFG HIPVLETSQC QLIYESVIAC EYLDDAYPGR KLFPYDPYER ARQKMLLELF
   121  CKVPHLTKEC LVALRCGREC TNLKAALRQE FSNLEEILEY QNTTFFGGTC ISMIDYLLWP
   181  WFERLDVYGI LDCVSHTPAL RLWISAMKWD PTVCALLMDK SIFQGFLNLY FQNNPNAFDF
   241  GLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSTO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

testis: 19 nTPM
pituitary gland: 9.8 nTPM
pancreas: 7.4 nTPM
skin: 7.1 nTPM
kidney: 6.4 nTPM
retina: 5.6 nTPM

Single-cell type

late spermatids: 560 nCPM
early spermatids: 488 nCPM
medullary thymic epithelial cells: 149 nCPM
gastric progenitor cells: 126 nCPM
somatotrophs: 118 nCPM
lactotrophs: 106 nCPM

Immune cell

neutrophil: 1.7 nTPM
T-reg: 1.2 nTPM
NK-cell: 1 nTPM
eosinophil: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM
gdT-cell: 0.5 nTPM

Brain region

basal ganglia: 21 nTPM
cerebral cortex: 20 nTPM
white matter: 19 nTPM
hypothalamus: 18 nTPM
amygdala: 17 nTPM
hippocampal formation: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSTO2 as an antibody target. Whether an autoantibody or antibody against GSTO2 could matter depends on whether native GSTO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSTO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GSTO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...