GSTM1

Protein identityUniProt · HPA

UniProt accession

P09488

Gene

GSTM1

Ensembl

ENSG00000134184

Chromosome

1

Canonical length

218 aa

Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Microtubules,Cytokinetic bridge,Primary cilium,Primary cilium tip,Primary cilium transition zone,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>P09488|GSTM1
     1  MPMILGYWDI RGLAHAIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL
    61  PYLIDGAHKI TQSNAILCYI ARKHNLCGET EEEKIRVDIL ENQTMDNHMQ LGMICYNPEF
   121  EKLKPKYLEE LPEKLKLYSE FLGKRPWFAG NKITFVDFLV YDVLDLHRIF EPKCLDAFPN
   181  LKDFISRFEG LEKISAYMKS SRFLPRPVFS KMAVWGNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSTM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

570 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.01

gnomAD pLI

0

gnomAD missense Z

1.52

DepMap mean gene effect

0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular detoxification of nitrogen compound
• glutathione derivative biosynthetic process
• glutathione metabolic process
• hepoxilin biosynthetic process
• nitrobenzene metabolic process
• prostaglandin metabolic process
• xenobiotic catabolic process

Molecular functions

• enzyme binding
• glutathione binding
• glutathione transferase activity
• protein homodimerization activity

Cellular components

• cytoplasm
• cytosol

Protein domainsUniProt · Pfam · InterPro

• Glutathione S-transferase, Mu class
• Glutathione S-transferase, N-terminal
• Glutathione S-transferase, C-terminal
• Glutathione S-transferase, C-terminal-like
• Thioredoxin-like superfamily
• Glutathione S-transferase, C-terminal domain superfamily
• Glutathione transferase family
• Glutathione S-transferase superfamily
• Glutathione S-transferase, C-terminal domain
• Glutathione S-transferase, N-terminal domain

KeywordsUniProt

• Cytoplasm
• Lipid metabolism
• Phosphoprotein
• Transferase