Seroatlas · Human Serome Atlas

GSTK1

Glutathione S-transferase kappa 1

Also known as: GST13, GSTK1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2Q3
Gene: GSTK1
Ensembl: ENSG00000197448
Chromosome: 7
Canonical length: 226 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Peroxisomes
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q9Y2Q3|GSTK1
     1  MGPLPRTVEL FYDVLSPYSW LGFEILCRYQ NIWNINLQLR PSLITGIMKD SGNKPPGLLP
    61  RKGLYMANDL KLLRHHLQIP IHFPKDFLSV MLEKGSLSAM RFLTAVNLEH PEMLEKASRE
   121  LWMRVWSRNE DITEPQSILA AAEKAGMSAE QAQGLLEKIA TPKVKNQLKE TTEAACRYGA
   181  FGLPITVAHV DGQTHMLFGS DRMELLAHLL GEKWMGPIPP AVNARL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSTK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 427 nTPM

Expression across tissuesHPA

Tissue

liver: 427 nTPM
choroid plexus: 342 nTPM
tongue: 302 nTPM
duodenum: 298 nTPM
parathyroid gland: 289 nTPM
small intestine: 261 nTPM

Single-cell type

late spermatids: 1,578 nCPM
early spermatids: 664 nCPM
enterocytes: 588 nCPM
hepatocytes: 370 nCPM
hofbauer cells: 359 nCPM
cytotrophoblasts: 356 nCPM

Immune cell

total PBMC: 917 nTPM
T-reg: 803 nTPM
non-classical monocyte: 645 nTPM
intermediate monocyte: 599 nTPM
memory CD4 T-cell: 556 nTPM
classical monocyte: 538 nTPM

Brain region

choroid plexus: 185 nTPM
white matter: 70 nTPM
medulla oblongata: 68 nTPM
midbrain: 65 nTPM
thalamus: 64 nTPM
pons: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Thioredoxin-like superfamily
DSBA-like thioredoxin domain
HCCA isomerase/glutathione S-transferase kappa
Glutathione S-transferase kappa
Glutathione S-transferase Kappa/NadH
DSBA-like thioredoxin domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GSTK1 as an antibody target. Whether an autoantibody or antibody against GSTK1 could matter depends on whether native GSTK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GSTK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GSTK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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