Seroatlas · Human Serome Atlas

GRIFIN

Grifin

Also known as: GRIFN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D1Z8
Gene: GRIFIN
Ensembl: ENSG00000275572
Chromosome: 7
Canonical length: 144 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>A4D1Z8|GRIFIN
     1  MAVQSKAFCA GGLAPGWKLL VQGHADSGED RFETNFLLET GDIAFHIKPR FSSATVVGNA
    61  FQYGRWGPEQ VSSIFPLAPG EPFEIEVSWD AEHFHVYAPE HKVLQFPCRQ RPLGATTRVR
   121  VLSDHCLAQV ELAKRGLSWG DRGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRIFIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

skin: 0.5 nTPM
choroid plexus: 0.3 nTPM
adipose tissue: 0.2 nTPM
adrenal gland: 0.1 nTPM
bone marrow: 0.1 nTPM
hypothalamus: 0.1 nTPM

Single-cell type

astrocytes: 1 nCPM
early spermatids: 1 nCPM
bergmann glia: 0.2 nCPM
retinal bipolar cells: 0.2 nCPM
ependymal cells: 0.1 nCPM
smooth muscle cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 5 nTPM
cerebellum: 4.5 nTPM
medulla oblongata: 4.4 nTPM
hippocampal formation: 3.7 nTPM
midbrain: 3.7 nTPM
pons: 3.5 nTPM

OntologyGO

Molecular functions

carbohydrate binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRIFIN as an antibody target. Whether an autoantibody or antibody against GRIFIN could matter depends on whether native GRIFIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRIFIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRIFIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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