Seroatlas · Human Serome Atlas

GRAPL

GRB2-related adapter protein-like

Also known as: GRAPL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TC17
Gene
GRAPL
Ensembl
ENSG00000189152
Chromosome
17
Canonical length
118 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome

OverviewNCBI Gene

Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in cell migration and enzyme-linked receptor protein signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>Q8TC17|GRAPL
     1  MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW
    61  YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN NRAQRGPCLG PKSHSRLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GRAPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 24 nTPM
  • tonsil: 24 nTPM
  • lymph node: 23 nTPM
  • appendix: 14 nTPM
  • small intestine: 11 nTPM
  • thymus: 8.3 nTPM

Single-cell type

  • lymphatic endothelial cells: 34 nCPM
  • b-cells: 17 nCPM
  • vascular endothelial cells: 8.8 nCPM
  • platelets: 2.8 nCPM
  • microglia: 2.5 nCPM
  • renal collecting duct principal cells: 2.1 nCPM

Immune cell

  • memory B-cell: 9.1 nTPM
  • naive B-cell: 3.8 nTPM
  • naive CD4 T-cell: 1.6 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • T-reg: 0.8 nTPM
  • total PBMC: 0.7 nTPM

Brain region

  • cerebral cortex: 7.5 nTPM
  • medulla oblongata: 7.5 nTPM
  • thalamus: 7.5 nTPM
  • amygdala: 7.4 nTPM
  • pons: 7.1 nTPM
  • midbrain: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0.31
gnomAD missense Z
0.65

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GRAPL as an antibody target. Whether an autoantibody or antibody against GRAPL could matter depends on whether native GRAPL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GRAPL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GRAPL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GRAPL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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