GPX7
Glutathione peroxidase 7
Also known as: FLJ14777, GPX6, GPX7_HUMAN, NPGPx
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96SL4
- Gene
- GPX7
- Ensembl
- ENSG00000116157
- Chromosome
- 1
- Canonical length
- 187 aa
- Protein class
- Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
Enables catalase activity. Predicted to be involved in cellular response to oxidative stress. Located in endoplasmic reticulum. Implicated in Barrett's adenocarcinoma and Barrett's esophagus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
187 residues, UniProt reviewed canonical sequence.
>Q96SL4|GPX7
1 MVAATVAAAW LLLWAAACAQ QEQDFYDFKA VNIRGKLVSL EKYRGSVSLV VNVASECGFT
61 DQHYRALQQL QRDLGPHHFN VLAFPCNQFG QQEPDSNKEI ESFARRTYSV SFPMFSKIAV
121 TGTGAHPAFK YLAQTSGKEP TWNFWKYLVA PDGKVVGAWD PTVSVEEVRP QITALVRKLI
181 LLKREDLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPX7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 28 nTPM
Expression across tissuesHPA
Tissue
- placenta: 28 nTPM
- choroid plexus: 23 nTPM
- ovary: 20 nTPM
- bone marrow: 17 nTPM
- thyroid gland: 16 nTPM
- lymph node: 15 nTPM
Single-cell type
- hepatic stellate cells: 78 nCPM
- decidual stromal cells: 63 nCPM
- megakaryocytes: 56 nCPM
- plasma cells: 39 nCPM
- granulosa cells: 35 nCPM
- megakaryocyte progenitors: 33 nCPM
Immune cell
- plasmacytoid DC: 74 nTPM
- naive CD4 T-cell: 45 nTPM
- naive B-cell: 35 nTPM
- memory CD4 T-cell: 35 nTPM
- memory B-cell: 32 nTPM
- MAIT T-cell: 32 nTPM
Brain region
- choroid plexus: 14 nTPM
- hypothalamus: 6.9 nTPM
- medulla oblongata: 5.6 nTPM
- cerebral cortex: 5.4 nTPM
- cerebellum: 5.3 nTPM
- midbrain: 5.3 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about GPX7.
Disease | AllUniProt
Conditions GPX7 is implicated in, by any mechanism.
- Barrett esophagus (BE) MIM:614266
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.18
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPX7 as an antibody target. Whether an autoantibody or antibody against GPX7 could matter depends on whether native GPX7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPX7 is annotated as secreted, so native GPX7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label GPX7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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