GPX6

Protein identityUniProt · HPA

UniProt accession

P59796

Gene

GPX6

Ensembl

ENSG00000198704

Chromosome

6

Canonical length

221 aa

Protein class

Enzymes, Metabolic proteins, Predicted secreted proteins

Secretome location

Secreted in male reproductive system

OverviewNCBI Gene

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. Expression of this gene has been observed in embryos and olfactory epithelium; however, the exact function of this gene is not known. This isozyme is a selenoprotein in humans, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The orthologs of this gene in mouse and rat (and some other species) contain a cysteine (Cys) residue in place of the Sec residue, and their corresponding mRNAs lack SECIS element. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>P59796|GPX6
     1  MFQQFQASCL VLFFLVGFAQ QTLKPQNRKV DCNKGVTGTI YEYGALTLNG EEYIQFKQFA
    61  GKHVLFVNVA AYUGLAAQYP ELNALQEELK NFGVIVLAFP CNQFGKQEPG TNSEILLGLK
   121  YVCPGSGFVP SFQLFEKGDV NGEKEQKVFT FLKNSCPPTS DLLGSSSQLF WEPMKVHDIR
   181  WNFEKFLVGP DGVPVMHWFH QAPVSTVKSD ILEYLKQFNT H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPX6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0

Highest tissue expression

3.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.56

gnomAD pLI

0

gnomAD missense Z

0.47

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• response to oxidative stress

Molecular functions

• glutathione peroxidase activity

Cellular components

• extracellular region

Protein domainsUniProt · Pfam · InterPro

• Glutathione peroxidase
• Glutathione peroxidase active site
• Glutathione peroxidase conserved site
• Thioredoxin-like superfamily
• Glutathione peroxidase

KeywordsUniProt

• Oxidoreductase
• Peroxidase
• Secreted
• Selenocysteine
• Signal