Seroatlas · Human Serome Atlas

GPX5

Epididymal secretory glutathione peroxidase

Also known as: GPX5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75715
Gene: GPX5
Ensembl: ENSG00000224586
Chromosome: 6
Canonical length: 221 aa
Protein class: Enzymes, Metabolic proteins, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>O75715|GPX5
     1  MTTQLRVVHL LPLLLACFVQ TSPKQEKMKM DCHKDEKGTI YDYEAIALNK NEYVSFKQYV
    61  GKHILFVNVA TYCGLTAQYP ELNALQEELK PYGLVVLGFP CNQFGKQEPG DNKEILPGLK
   121  YVRPGGGFVP SFQLFEKGDV NGEKEQKVFS FLKHSCPHPS EILGTFKSIS WDPVKVHDIR
   181  WNFEKFLVGP DGIPVMRWSH RATVSSVKTD ILAYLKQFKT K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 8.7 nTPM

Expression across tissuesHPA

Tissue

epididymis: 8.7 nTPM
testis: 1.1 nTPM
seminal vesicle: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

epididymal principal cells: 10 nCPM
late spermatids: 6.6 nCPM
late primary spermatocytes: 1.5 nCPM
early spermatids: 1 nCPM
brain excitatory neurons: 0.1 nCPM
brain inhibitory neurons: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

glutathione peroxidase activity

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPX5 as an antibody target. Whether an autoantibody or antibody against GPX5 could matter depends on whether native GPX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPX5 is annotated as secreted, so native GPX5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label GPX5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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