Seroatlas · Human Serome Atlas

GPSM3

G-protein-signaling modulator 3

Also known as: AGS4, C6orf9, G18, G18.1a, G18.1b, G18.2, GPSM3_HUMAN, NG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4H4
Gene: GPSM3
Ensembl: ENSG00000213654
Chromosome: 6
Canonical length: 160 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase regulator activity. Predicted to be involved in positive regulation of inflammatory response. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of leukocyte chemotaxis. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q9Y4H4|GPSM3
     1  MEAERPQEEE DGEQGPPQDE EGWPPPNSTT RPWRSAPPSP PPPGTRHTAL GPRSASLLSL
    61  QTELLLDLVA EAQSRRLEEQ RATFYTPQNP SSLAPAPLRP LEDREQLYST ILSHQCQRME
   121  AQRSEPPLPP GGQELLELLL RVQGGGRMEE QRSRPPTHTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPSM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 235 nTPM

Expression across tissuesHPA

Tissue

spleen: 235 nTPM
bone marrow: 152 nTPM
lymph node: 131 nTPM
tonsil: 94 nTPM
appendix: 91 nTPM
thymus: 77 nTPM

Single-cell type

microglia: 32 nCPM
megakaryocytes: 19 nCPM
neutrophils: 17 nCPM
platelets: 14 nCPM
b-cells: 8.9 nCPM
nk-cells: 8.1 nCPM

Immune cell

neutrophil: 246 nTPM
eosinophil: 195 nTPM
intermediate monocyte: 73 nTPM
non-classical monocyte: 72 nTPM
myeloid DC: 58 nTPM
classical monocyte: 56 nTPM

Brain region

medulla oblongata: 17 nTPM
thalamus: 15 nTPM
white matter: 14 nTPM
pons: 13 nTPM
hypothalamus: 13 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0.29
gnomAD missense Z: 0.87
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

GoLoco motif
Tetratricopeptide-like helical domain superfamily
GoLoco motif
G-protein-signaling modulator 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPSM3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPSM3 as an antibody target. Whether an autoantibody or antibody against GPSM3 could matter depends on whether native GPSM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPSM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPSM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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