Seroatlas · Human Serome Atlas

GPR83

G-protein coupled receptor 83

Also known as: GPR72, GPR83_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYM4
Gene: GPR83
Ensembl: ENSG00000123901
Chromosome: 11
Canonical length: 423 aa
Protein class: G-protein coupled receptors, Plasma proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

Predicted to enable neuropeptide receptor activity. Predicted to be involved in neuropeptide signaling pathway and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within response to glucocorticoid. Located in cilium. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

423 residues, UniProt reviewed canonical sequence.

>Q9NYM4|GPR83
     1  MVPHLLLLCL LPLVRATEPH EGRADEQSAE AALAVPNASH FFSWNNYTFS DWQNFVGRRR
    61  YGAESQNPTV KALLIVAYSF IIVFSLFGNV LVCHVIFKNQ RMHSATSLFI VNLAVADIMI
   121  TLLNTPFTLV RFVNSTWIFG KGMCHVSRFA QYCSLHVSAL TLTAIAVDRH QVIMHPLKPR
   181  ISITKGVIYI AVIWTMATFF SLPHAICQKL FTFKYSEDIV RSLCLPDFPE PADLFWKYLD
   241  LATFILLYIL PLLIISVAYA RVAKKLWLCN MIGDVTTEQY FALRRKKKKT IKMLMLVVVL
   301  FALCWFPLNC YVLLLSSKVI RTNNALYFAF HWFAMSSTCY NPFIYCWLNE NFRIELKALL
   361  SMCQRPPKPQ EDRPPSPVPS FRVAWTEKND GQRAPLANNL LPTSQLQSGK TDLSSVEPIV
   421  TMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR83 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 15 nTPM
hypothalamus: 4.9 nTPM
cerebral cortex: 3.2 nTPM
hippocampal formation: 3.1 nTPM
thyroid gland: 2.8 nTPM
basal ganglia: 2.2 nTPM

Single-cell type

other brain neurons: 8.7 nCPM
schwann cells: 6.7 nCPM
brain excitatory neurons: 6.4 nCPM
brain inhibitory neurons: 5.6 nCPM
endometrial ciliated cells: 2.9 nCPM
breast hormone-responsive cells: 1.1 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM

Brain region

cerebellum: 29 nTPM
midbrain: 15 nTPM
hippocampal formation: 14 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: -0.56
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR83 as an antibody target. Whether an autoantibody or antibody against GPR83 could matter depends on whether native GPR83 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR83 is annotated at the cell surface, where native GPR83 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR83 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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