Seroatlas · Human Serome Atlas

GPR39

G-protein coupled receptor 39

Also known as: GPR39_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43194
Gene
GPR39
Ensembl
ENSG00000183840
Chromosome
2
Canonical length
453 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>O43194|GPR39
     1  MASPSLPGSD CSQIIDHSHV PEFEVATWIK ITLILVYLII FVMGLLGNSA TIRVTQVLQK
    61  KGYLQKEVTD HMVSLACSDI LVFLIGMPME FYSIIWNPLT TSSYTLSCKL HTFLFEACSY
   121  ATLLHVLTLS FERYIAICHP FRYKAVSGPC QVKLLIGFVW VTSALVALPL LFAMGTEYPL
   181  VNVPSHRGLT CNRSSTRHHE QPETSNMSIC TNLSSRWTVF QSSIFGAFVV YLVVLLSVAF
   241  MCWNMMQVLM KSQKGSLAGG TRPPQLRKSE SEESRTARRQ TIIFLRLIVV TLAVCWMPNQ
   301  IRRIMAAAKP KHDWTRSYFR AYMILLPFSE TFFYLSSVIN PLLYTVSSQQ FRRVFVQVLC
   361  CRLSLQHANH EKRLRVHAHS TTDSARFVQR PLLFASRRQS SARRTEKIFL STFQSEAEPQ
   421  SKSQSLSLES LEPNSGAKPA NSAAENGFQE HEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
6.3 nTPM

Expression across tissuesHPA

Tissue

  • colon: 6.3 nTPM
  • stomach: 5.7 nTPM
  • rectum: 5.3 nTPM
  • parathyroid gland: 4.8 nTPM
  • duodenum: 4.3 nTPM
  • cervix: 4.1 nTPM

Single-cell type

  • alveolar cells type 1: 300 nCPM
  • transitional alveolar cells: 253 nCPM
  • distal convoluted tubule cells: 133 nCPM
  • renal collecting duct principal cells: 130 nCPM
  • ependymal cells: 127 nCPM
  • renal connecting tubule cells: 126 nCPM

Immune cell

  • plasmacytoid DC: 1.3 nTPM
  • myeloid DC: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • midbrain: 5.4 nTPM
  • medulla oblongata: 5 nTPM
  • pons: 4 nTPM
  • spinal cord: 3.4 nTPM
  • choroid plexus: 3.3 nTPM
  • cerebral cortex: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.81
gnomAD pLI
0
gnomAD missense Z
0.36
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR39 as an antibody target. Whether an autoantibody or antibody against GPR39 could matter depends on whether native GPR39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR39 is annotated at the cell surface, where native GPR39 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GPR39. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...