Seroatlas · Human Serome Atlas

GPATCH4

G patch domain-containing protein 4

Also known as: GPTC4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T3I0
Gene: GPATCH4
Canonical length: 446 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for GPATCH4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q5T3I0|GPATCH4
     1  MNVTPEVKSR GMKFAEEQLL KHGWTQGKGL GRKENGITQA LRVTLKQDTH GVGHDPAKEF
    61  TNHWWNELFN KTAANLVVET GQDGVQIRSL SKETTRYNHP KPNLLYQKFV KMATLTSGGE
   121  KPNKDLESCS DDDNQGSKSP KILTDEMLLQ ACEGRTAHKA ARLGITMKAK LARLEAQEQA
   181  FLARLKGQDP GAPQLQSESK PPKKKKKKRR QKEEEEATAS ERNDADEKHP EHAEQNIRKS
   241  KKKKRRHQEG KVSDEREGTT KGNEKEDAAG TSGLGELNSR EQTNQSLRKG KKKKRWHHEE
   301  EKMGVLEEGG KGKEAAGSVR TEEVESRAYA DPCSRRKKRQ QQEEEDLNLE DRGEETVLGG
   361  GTREAESRAC SDGRSRKSKK KRQQHQEEED ILDVRDEKDG GAREAESRAH TGSSSRGKRK
   421  RQQHPKKERA GVSTVQKAKK KQKKRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPATCH4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 65 nTPM
tongue: 26 nTPM
adipose tissue: 20 nTPM
cerebral cortex: 19 nTPM
urinary bladder: 18 nTPM
esophagus: 18 nTPM

Single-cell type

esophageal basal cells: 122 nCPM
gastric progenitor cells: 91 nCPM
erythrocyte progenitors: 89 nCPM
basal keratinocytes: 87 nCPM
hepatic stellate cells: 78 nCPM
esophageal suprabasal cells: 76 nCPM

Immune cell

naive B-cell: 22 nTPM
memory B-cell: 20 nTPM
naive CD8 T-cell: 17 nTPM
memory CD8 T-cell: 17 nTPM
memory CD4 T-cell: 16 nTPM
non-classical monocyte: 15 nTPM

Brain region

cerebral cortex: 25 nTPM
white matter: 20 nTPM
midbrain: 18 nTPM
pons: 17 nTPM
medulla oblongata: 17 nTPM
hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.7

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

RNA binding

Cellular components

nucleolus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPATCH4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NPM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPATCH4 as an antibody target. Whether an autoantibody or antibody against GPATCH4 could matter depends on whether native GPATCH4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPATCH4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPATCH4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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