GOLGA8F
Golgin subfamily A member 8F
Also known as: GOG8F_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- P0DX52
- Gene
- GOLGA8F
- Canonical length
- 636 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
No narrative summary is available for GOLGA8F in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
636 residues, UniProt reviewed canonical sequence.
>P0DX52|GOLGA8F
1 MAEETRQSKL AAAKRKLKEY WQRNSPGVPA GAKRNRKTNG SIHETATSGG CHSPGDSATG
61 IHGESPTSSA TLKDLESPCQ ELAVVPDSRS VKVSQLKNTI KSLKQQNKQV EHQLEEEKKA
121 NNEKQKAERE LEVQIQRLNI QKGKLNTDLY HTKRSLRYFE EESKDLAVRL QHSLQRKGEL
181 ERALSAVTAT QKKKAERQFS SRSKARMEWK LEQSMREQAL LKAQLTQLKE SLKEVQLERD
241 EYAEHLKGER ARWQQRMRKM SQEVCSLKKE KKHDKYRVEK LERSLSKLKH QMAEPLPPEP
301 PAVPSEVELQ HLRKELERVA GELQAQVEYN QRISLLNEGQ KERLREQEER LQEQQERLPE
361 QEERLQQLAE PQNSFKELNN ENKSVLQLEQ QVKELQEKLG KERLEAASQQ KQQLTAQLSL
421 MALPGEGDGG GHLDSEGEEA PRPIPSIPQD LESREAMSGF MDHLEEKADL SELVEKEELG
481 FFQYYRERCH QKVYHPITKP GGSAKDAAPG GGHHQAGPGQ GGDEGEAAGA AGDGVAAGGD
541 YKGHSKFLVT AQNPAHEPSP GAPAPQELGA AHKHGDLCEV SLTDSVEPVQ GEAREGSPHD
601 NPTAQPIVQD HQEHPGLGSN CCVPFFCWAW LPRRRRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GOLGA8F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.6
- Highest tissue expression
- 0.1 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 0.1 nTPM
- testis: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- late primary spermatocytes: 0.5 nCPM
- early primary spermatocytes: 0.3 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.63
- gnomAD pLI
- 0.05
- gnomAD missense Z
- -0.03
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GOLGA8F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GOLGA8F as an antibody target. Whether an autoantibody or antibody against GOLGA8F could matter depends on whether native GOLGA8F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GOLGA8F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GOLGA8F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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