Seroatlas · Human Serome Atlas

GLRA3

Glycine receptor subunit alpha-3

Also known as: GLRA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75311
Gene: GLRA3
Ensembl: ENSG00000145451
Chromosome: 4
Canonical length: 464 aa
Protein class: FDA approved drug targets, Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Plasma membrane
Quaternary structure: Homopentamer

OverviewNCBI Gene

This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>O75311|GLRA3
     1  MAHVRHFRTL VSGFYFWEAA LLLSLVATKE TDSARSRSAP MSPSDFLDKL MGRTSGYDAR
    61  IRPNFKGPPV NVTCNIFINS FGSIAETTMD YRVNIFLRQK WNDPRLAYSE YPDDSLDLDP
   121  SMLDSIWKPD LFFANEKGAN FHEVTTDNKL LRIFKNGNVL YSIRLTLTLS CPMDLKNFPM
   181  DVQTCIMQLE SFGYTMNDLI FEWQDEAPVQ VAEGLTLPQF LLKEEKDLRY CTKHYNTGKF
   241  TCIEVRFHLE RQMGYYLIQM YIPSLLIVIL SWVSFWINMD AAPARVALGI TTVLTMTTQS
   301  SGSRASLPKV SYVKAIDIWM AVCLLFVFSA LLEYAAVNFV SRQHKELLRF RRKRKNKTEA
   361  FALEKFYRFS DMDDEVRESR FSFTAYGMGP CLQAKDGMTP KGPNHPVQVM PKSPDEMRKV
   421  FIDRAKKIDT ISRACFPLAF LIFNIFYWVI YKILRHEDIH QQQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLRA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 5.2 nTPM
hypothalamus: 2.5 nTPM
breast: 1.9 nTPM
midbrain: 1.4 nTPM
amygdala: 1.1 nTPM
adrenal gland: 0.7 nTPM

Single-cell type

retinal amacrine cells: 116 nCPM
other brain neurons: 73 nCPM
gonadotrophs: 63 nCPM
brain excitatory neurons: 60 nCPM
breast hormone-responsive cells: 55 nCPM
early spermatids: 42 nCPM

Immune cell

memory B-cell: 0.4 nTPM
basophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 29 nTPM
basal ganglia: 16 nTPM
midbrain: 15 nTPM
cerebral cortex: 13 nTPM
amygdala: 12 nTPM
thalamus: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 0.98
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLRA3 as an antibody target. Whether an autoantibody or antibody against GLRA3 could matter depends on whether native GLRA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLRA3 is annotated at the cell surface, where native GLRA3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GLRA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...