Seroatlas · Human Serome Atlas

GIPC1

PDZ domain-containing protein GIPC1

Also known as: C19orf3, GIPC, GIPC1_HUMAN, GLUT1CBP, Hs.6454, NIP, RGS19IP1, SEMCAP, SYNECTIN, TIP-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14908
Gene
GIPC1
Ensembl
ENSG00000123159
Chromosome
19
Canonical length
333 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>O14908|GIPC1
     1  MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP PPALRPRLVF
    61  HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC TLNTHKVDMD KLLGGQIGLE
   121  DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIH LISVGDMIEA
   181  INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR
   241  GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL
   301  AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIPC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
338 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 338 nTPM
  • skin: 144 nTPM
  • vagina: 134 nTPM
  • spinal cord: 129 nTPM
  • colon: 114 nTPM
  • cervix: 113 nTPM

Single-cell type

  • esophageal apical cells: 1,929 nCPM
  • esophageal suprabasal cells: 625 nCPM
  • colonocytes: 463 nCPM
  • breast lactating cells: 359 nCPM
  • suprabasal keratinocytes: 306 nCPM
  • alveolar cells type 1: 303 nCPM

Immune cell

  • T-reg: 12 nTPM
  • gdT-cell: 5.2 nTPM
  • memory CD4 T-cell: 5.1 nTPM
  • memory CD8 T-cell: 5.1 nTPM
  • MAIT T-cell: 4.7 nTPM
  • naive CD4 T-cell: 4.2 nTPM

Brain region

  • midbrain: 104 nTPM
  • basal ganglia: 104 nTPM
  • thalamus: 103 nTPM
  • white matter: 102 nTPM
  • medulla oblongata: 101 nTPM
  • cerebellum: 99 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GIPC1.

Disease | AllUniProt

Conditions GIPC1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0.01
gnomAD missense Z
0.54
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GIPC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIPC1 as an antibody target. Whether an autoantibody or antibody against GIPC1 could matter depends on whether native GIPC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIPC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GIPC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GIPC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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