GGTLC1
Glutathione hydrolase light chain 1
Also known as: dJ831C21.1, dJ831C21.2, GGTL1_HUMAN, GGTLA3, GGTLA4
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BX51
- Gene
- GGTLC1
- Ensembl
- ENSG00000149435
- Chromosome
- 20
- Canonical length
- 225 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
OverviewNCBI Gene
This gene encodes a member of the gamma-glutamyl transpeptidase (GGT) family, which are important in the metabolism of glutathione. The most ubiquitously expressed human GGT gene, GGT1, encodes a single transmembrane polypeptide that is post-translationally processed to form a heavy and a light chain. In contrast, the product of this gene only contains homology to the light chain region, and lacks a transmembrane domain. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]
Canonical amino-acid sequenceUniProt
225 residues, UniProt reviewed canonical sequence.
>Q9BX51|GGTLC1
1 MTSEFFSAQL RAQISDDTTH PISYYKPEFY MPDDGGTAHL SVVAEDGSAV SATSTINLYF
61 GSKVRSPVSG ILLNNEMDDF SSTSITNEFG VPPSPANFIQ PGKQPLSSMC PTIMVGQDGQ
121 VRMVVGAAGG TQITMATALA IIYNLWFGYD VKWAVEEPRL HNQLLPNVTT VERNIDQEVT
181 AALETRHHHT QITSTFIAVV QAIVRMAGGW AAASDSRKGG EPAGYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GGTLC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 31 nTPM
Expression across tissuesHPA
Tissue
- lung: 31 nTPM
- testis: 17 nTPM
- thyroid gland: 2 nTPM
- kidney: 0.4 nTPM
- pancreas: 0.4 nTPM
- duodenum: 0.2 nTPM
Single-cell type
- late spermatids: 226 nCPM
- alveolar cells type 1: 203 nCPM
- late primary spermatocytes: 85 nCPM
- early spermatids: 40 nCPM
- transitional alveolar cells: 37 nCPM
- alveolar cells type 2: 26 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 0.4 nTPM
- hypothalamus: 0.2 nTPM
- thalamus: 0.2 nTPM
- amygdala: 0.1 nTPM
- basal ganglia: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.68
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.18
- DepMap mean gene effect
- -0.22
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GGTLC1 as an antibody target. Whether an autoantibody or antibody against GGTLC1 could matter depends on whether native GGTLC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GGTLC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GGTLC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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