Seroatlas · Human Serome Atlas

GGT6

Glutathione hydrolase 6

Also known as: FLJ90165, GGT6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P531
Gene: GGT6
Ensembl: ENSG00000167741
Chromosome: 17
Canonical length: 493 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q6P531|GGT6
     1  MERAEEPVVY QKLLPWEPSL ESEEEVEEEE TSEALVLNPR RHQDSSRNKA GGLPGTWARV
    61  VAALLLLAVG CSLAVRQLQN QGRSTGSLGS VAPPPGGHSH GPGVYHHGAI ISPAGRELLV
   121  AGGNVVDAGV GAALCLAVVH PHATGLGAMF WGLFHDSSSG NSTALTSGPA QTLAPGLGLP
   181  AALPTLHLLH ARFGRLPWPR LLVGPTTLAQ EGFLVDTPLA RALVARGTEG LCPLLCHADG
   241  TPLGAGARAT NPQLAAVLRS AALAPTSDLA GDALLSLLAG DLGVEVPSAV PRPTLEPAEQ
   301  LPVPQGILFT TPSPSAGPEL LALLEAALRS GAPIPDPCPP FLQTAVSPES SALAAVDSSG
   361  SVLLLTSSLN CSFGSAHLSP STGVLLSNLV AKSTTSAWAC PLILRGSLDD TEADVLGLVA
   421  SGTPDVARAM THTLLRHLAA RPPTQAQHQH QGQQEPTEHP STCGQGTLLQ VAAHTEHAHV
   481  SSVPHACCPF QGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GGT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 53 nTPM
skin: 51 nTPM
colon: 50 nTPM
esophagus: 50 nTPM
pancreas: 44 nTPM
duodenum: 42 nTPM

Single-cell type

esophageal apical cells: 329 nCPM
colonocytes: 177 nCPM
esophageal suprabasal cells: 118 nCPM
enterocytes: 111 nCPM
epididymal principal cells: 93 nCPM
enteric transient amplifying cells: 87 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.3 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

white matter: 2.9 nTPM
cerebellum: 2.5 nTPM
cerebral cortex: 2.5 nTPM
hippocampal formation: 2.3 nTPM
choroid plexus: 2.2 nTPM
medulla oblongata: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleophile aminohydrolases, N-terminal
Gamma-glutamyltranspeptidase, small subunit, C-terminal domain
Gamma-glutamyltranspeptidase
Gamma-glutamyltransferase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GGT6 as an antibody target. Whether an autoantibody or antibody against GGT6 could matter depends on whether native GGT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GGT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GGT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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